Blar i Department of Clinical Medicine på forfatter "Basam, Mudaser"
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Changes in Immune Cell Types with Age in Breast are Consistent with a Decline in Immune Surveillance and Increased Immunosuppression
Zirbes, Arrianna; Joseph, Jesuchristopher; Lopez, Jennifer C.; Sayaman, Rosalyn W.; Basam, Mudaser; Seewaldt, Victoria; LaBarge, Mark A. (Journal article; Peer reviewed, 2021)A majority of breast cancers (BC) are age-related and we seek to determine what cellular and molecular changes occur in breast tissue with age that make women more susceptible to cancer initiation. Immune-epithelial cell ... -
Loss of epigenetic suppression of retrotransposons with oncogenic potential in aging mammary luminal epithelial cells
Senapati, Parijat; Miyano, Masaru; Sayaman, Rosalyn W.; Basam, Mudaser; Leung, Amy; LaBarge, Mark; Schones, Dustin E. (Journal article; Peer reviewed, 2023)A primary function of DNA methylation in mammalian genomes is to repress transposable elements (TEs). The widespread methylation loss that is commonly observed in cancer cells results in the loss of epigenetic repression ...