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dc.contributor.authorThorsteinsdottir, Hjørdis
dc.contributor.authorSalvador, Cathrin Lytomt
dc.contributor.authorMjøen, Geir
dc.contributor.authorLie, Anine
dc.contributor.authorSugulle, Meryam
dc.contributor.authorTøndel, Camilla
dc.contributor.authorBrun, Atle
dc.contributor.authorAlmaas, Runar
dc.contributor.authorBjerre, Anna Kristina
dc.PublishedDisease Markers. 2020, .
dc.description.abstractGrowth differentiation factor 15 (GDF-15) is strongly associated with cardiovascular disease (CVD). The aim of our study was to evaluate plasma and urinary levels of GDF-15 after pediatric renal transplantation (Rtx) and in children with chronic kidney disease (CKD) and its associations to cardiovascular risk factors. In this cross-sectional study, GDF-15 was measured in plasma and urine from 53 children with a renal transplant and 83 children with CKD and related to cardiovascular risk factors (hypertension, obesity, and cholesterol) and kidney function. Forty healthy children served as a control group. Plasma levels of GDF-15 (median and range) for a Tx (transplantation) cohort, CKD cohort, and healthy controls were, respectively, 865 ng/L (463-3039 ng/L), 508 ng/L (183-3279 ng/L), and 390 ng/L (306-657 ng/L). The CKD and Tx cohorts both had significantly higher GDF-15 levels than the control group (p < 0:001). Univariate associations between GDF-15 and hyperuricemia (p < 0:001), elevated triglycerides (p = 0:028), low HDL (p = 0:038), and obesity (p = 0:028) were found. However, mGFR (p < 0:001) and hemoglobin (p < 0:001) were the only significant predictors of GDF-15 in an adjusted analysis. Urinary GDF15/creatinine ratios were 448 ng/mmol (74–5013 ng/mmol) and 540 ng/mmol (5–14960 ng/mmol) in the Tx cohort and CKD cohort, respectively. In the CKD cohort, it was weakly correlated to mGFR (r = −0:343, p = 0:002). Plasma levels of GDF-15 are elevated in children with CKD and after Rtx. The levels were not associated with traditional cardiovascular risk factors but strongly associated with renal function.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleGrowth Differentiation Factor 15 in Children with Chronic Kidney Disease and after Renal Transplantationen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2020 Hjordis Thorsteinsdottir et al.en_US
dc.source.journalDisease Markersen_US
dc.identifier.citationDisease Markers. 2020, 6162892.en_US

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