Vis enkel innførsel

dc.contributor.authorAanestad, Eivind
dc.contributor.authorGilhus, Nils Erik
dc.contributor.authorBrøgger, Jan
dc.date.accessioned2021-03-30T10:51:32Z
dc.date.available2021-03-30T10:51:32Z
dc.date.created2020-08-13T12:32:08Z
dc.date.issued2020-01
dc.PublishedClinical Neurophysiology. 2020, 131 (1), 25-33.
dc.identifier.issn1388-2457
dc.identifier.urihttps://hdl.handle.net/11250/2736112
dc.description.abstractObjective To investigate whether the occurrence and morphology of interictal epileptiform discharges (IEDs) in scalp-EEG change by age. Methods 10,547 patients who had a standard or sleep deprived EEG recording reported using the SCORE standard were included. 875 patients had at least one EEG with focal IEDs. Focal IED morphology was analyzed by age using quantitative measures in EEGLAB and by visual classification based on the SCORE standard. We present distributions of IED measures by age group, with medians, interquartiles, 5th and 95th percentiles. Results Focal IEDs occurred most frequently in children and elderly. IED morphology and localization depended on age (p < 0.001). IEDs had higher amplitudes, sharper peaks, larger slopes, shorter durations, larger slow-wave areas and wider distributions in children. These morphological characteristics diminished and the IEDs became more lateralized with increasing age. Spike asymmetry was stable across all age groups. Conclusions IEDs have age-dependent characteristics. A spike detector, human or computer, should not operate with the same set of thresholds for patients at various age. With increasing age, focal IEDs are less sharp, have lower amplitudes, have less prominent slow-waves and they become more lateralized. Our findings can help EEG readers in detecting and correctly describing IEDs in patients of various age. Significance EEG readers should always consider patient age when interpreting interictal epileptiform discharges.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleInterictal epileptiform discharges vary across age groupsen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2019 International Federation of Clinical Neurophysiologyen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.doi10.1016/j.clinph.2019.09.017
dc.identifier.cristin1823156
dc.source.journalClinical Neurophysiologyen_US
dc.source.40131
dc.source.141
dc.source.pagenumber25-33en_US
dc.identifier.citationClinical Neurophysiology. 2020, 131 (1), 25-33en_US
dc.source.volume131en_US
dc.source.issue1en_US


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Navngivelse 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse 4.0 Internasjonal