dc.contributor.author | Waldenström, Jesper | |
dc.contributor.author | Nyström, Kristina | |
dc.contributor.author | Nilsson, Staffan | |
dc.contributor.author | Norkrans, Gunnar | |
dc.contributor.author | Ydreborg, Magdalena | |
dc.contributor.author | Langeland, Nina | |
dc.contributor.author | Mørch, Kristine | |
dc.contributor.author | Westin, Johan | |
dc.contributor.author | Lagging, Martin | |
dc.date.accessioned | 2021-04-22T11:23:02Z | |
dc.date.available | 2021-04-22T11:23:02Z | |
dc.date.created | 2020-10-07T19:49:22Z | |
dc.date.issued | 2020 | |
dc.Published | PLOS ONE. 2020, 15:e0237840 (8), 1-16. | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://hdl.handle.net/11250/2739120 | |
dc.description.abstract | Background and objectives
The hydroxylation to 25-hydroxy vitamin D (25(OH)D) occurs in the liver and the impact of liver disease on vitamin D is unclear. This study evaluated the relationship between vitamin D concentrations and hepatic histopathology, seasonality and patient characteristics in well-characterized patients having undergone a liver biopsy.
Method
25(OH)D was measured post-hoc in pre-treatment serum from 331 North European patients with chronic HCV genotype 2 or 3 infection (NORDynamIC study). Liver biopsies were scored for fibrosis and inflammation according to the Ishak protocol, and graded for steatosis. Non-invasive markers of hepatic fibrosis as well as baseline viral and host characteristics, including genetic polymorphisms rs2228570, rs7975232, and rs10877012 were also evaluated.
Results
Mean 25(OH)D concentration was 59 ±23 nmol/L, with 41% having values <50 nmol/L and 6% were <30 nmol/L. 25(OH)D correlated with fibrosis (r = -0.10, p ≤0.05) in univariate but not in multivariate analyses. No association was observed between 25(OH)D and hepatic inflammation, but with steatosis in HCV genotype 2 infected patients. None of the genetic polymorphisms impacted on 25(OH)D levels or fibrosis. 25(OH)D levels were significantly inversely correlated to BMI (r = -0.19, p = 0.001), and was also associated with season and non-Caucasian ethnicity.
Conclusion
Fibrosis was not independently associated with 25(OH)D concentration and no association was seen with hepatic inflammation, but HCV genotype 2 infected patients with moderate-to-severe steatosis had lower 25(OH)D levels compared to those without steatosis. A high percentage had potential risk of 25(OH)D deficiency, and BMI, seasonality and ethnicity were independently associated with 25(OH)D as previously reported. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Public Library of Science | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | The relation of 25-hydroxy vitamin D concentrations to liver histopathology, seasonality and baseline characteristics in chronic hepatitis C virus genotype 2 or 3 infection | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright © 2020 Waldenström et al. | en_US |
dc.source.articlenumber | e0237840 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1371/journal.pone.0237840 | |
dc.identifier.cristin | 1838040 | |
dc.source.journal | PLOS ONE | en_US |
dc.source.40 | 15:e0237840 | |
dc.source.14 | 8 | |
dc.identifier.citation | PLOS ONE. 2020, 15 (8), e0237840. | en_US |
dc.source.volume | 15 | en_US |
dc.source.issue | 8 | en_US |