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dc.contributor.authorJain, Ruchi
dc.contributor.authorÖzgümüs, Türküler
dc.contributor.authorJensen, Troels Mygind
dc.contributor.authordu Plessis, Elsa
dc.contributor.authorKeindl, Magdalena
dc.contributor.authorMøller, Cathrine Laustrup
dc.contributor.authorFalhammar, Henrik
dc.contributor.authorNyström, Thomas
dc.contributor.authorCatrina, Sergiu-Bogdan
dc.contributor.authorJörneskog, Gun
dc.contributor.authorJessen, Leon Eyrich
dc.contributor.authorForsblom, Carol
dc.contributor.authorHaukka, Jani K.
dc.contributor.authorGroop, Per-Henrik
dc.contributor.authorRossing, Peter
dc.contributor.authorGroop, Leif
dc.contributor.authorEliasson, Mats
dc.contributor.authorEliasson, Björn
dc.contributor.authorBrismar, Kerstin
dc.contributor.authorAl-Majdoub, Mahmoud
dc.contributor.authorNilsson, Peter M.
dc.contributor.authorTaskinen, Marja-Riitta
dc.contributor.authorFerrannini, Ele
dc.contributor.authorSpégel, Peter
dc.contributor.authorBerg, Tore Julsrud
dc.contributor.authorLyssenko, Valeriya
dc.date.accessioned2021-04-23T12:50:31Z
dc.date.available2021-04-23T12:50:31Z
dc.date.created2020-09-09T12:46:03Z
dc.date.issued2020
dc.PublishedScientific Reports. 2020, 10:11561 1-12.
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/11250/2739376
dc.description.abstractIdentification of biomarkers associated with protection from developing diabetic complications is a prerequisite for an effective prevention and treatment. The aim of the present study was to identify clinical and plasma metabolite markers associated with freedom from vascular complications in people with very long duration of type 1 diabetes (T1D). Individuals with T1D, who despite having longer than 30 years of diabetes duration never developed major macro- or microvascular complications (non-progressors; NP) were compared with those who developed vascular complications within 25 years from diabetes onset (rapid progressors; RP) in the Scandinavian PROLONG (n = 385) and DIALONG (n = 71) cohorts. The DIALONG study also included 75 healthy controls. Plasma metabolites were measured using gas and/or liquid chromatography coupled to mass spectrometry. Lower hepatic fatty liver indices were significant common feature characterized NPs in both studies. Higher insulin sensitivity and residual ß-cell function (C-peptide) were also associated with NPs in PROLONG. Protection from diabetic complications was associated with lower levels of the glycolytic metabolite pyruvate and APOCIII in PROLONG, and with lower levels of thiamine monophosphate and erythritol, a cofactor and intermediate product in the pentose phosphate pathway as well as higher phenylalanine, glycine and serine in DIALONG. Furthermore, T1D individuals showed elevated levels of picolinic acid as compared to the healthy individuals. The present findings suggest a potential beneficial shunting of glycolytic substrates towards the pentose phosphate and one carbon metabolism pathways to promote nucleotide biosynthesis in the liver. These processes might be linked to higher insulin sensitivity and lower liver fat content, and might represent a mechanism for protection from vascular complications in individuals with long-term T1D.en_US
dc.language.isoengen_US
dc.publisherNatureen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleLiver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetesen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2020 The Authorsen_US
dc.source.articlenumber11561en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1038/s41598-020-68130-y
dc.identifier.cristin1828386
dc.source.journalScientific Reportsen_US
dc.source.4010:11561
dc.identifier.citationScientific Reports. 2020, 10:11561en_US
dc.source.volume10en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal