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dc.contributor.authorKoenig, Julian
dc.contributor.authorAbler, Birgit
dc.contributor.authorAgartz, Ingrid
dc.contributor.authorÅkerstedt, Torbjørn
dc.contributor.authorAndreassen, Ole Andreas
dc.contributor.authorAnthony, Mia
dc.contributor.authorBär, Karl-Jürgen
dc.contributor.authorBertsch, Katja
dc.contributor.authorBrown, Rebecca C.
dc.contributor.authorBrunner, Romuald
dc.contributor.authorCarnevali, Luca
dc.contributor.authorCritchley, Hugo D.
dc.contributor.authorCullen, Kathryn R
dc.contributor.authorde Geus, Eco J C
dc.contributor.authorde la Cruz, Feliberto
dc.contributor.authorDziobek, Isabel
dc.contributor.authorFerger, Marc D.
dc.contributor.authorFischer, Håkan
dc.contributor.authorFlor, Herta
dc.contributor.authorGaebler, Michael
dc.contributor.authorGianaros, Peter J.
dc.contributor.authorGiummarra, Melita J.
dc.contributor.authorGreening, Steven G.
dc.contributor.authorGuendelman, Simon
dc.contributor.authorHeathers, James A. J.
dc.contributor.authorHerpertz, Sabine C.
dc.contributor.authorHu, Mandy X.
dc.contributor.authorJentschke, Sebastian
dc.contributor.authorKaess, Michael
dc.contributor.authorKaufmann, Tobias
dc.contributor.authorKlimes-Dougan, Bonnie
dc.contributor.authorKoelsch, Stefan
dc.contributor.authorKrauch, Marlene
dc.contributor.authorKumral, Deniz
dc.contributor.authorLamers, Femke
dc.contributor.authorLee, Tae‐Ho
dc.contributor.authorLekander, Mats
dc.contributor.authorLin, Feng
dc.contributor.authorLotze, Martin
dc.contributor.authorMakovac, Elena
dc.contributor.authorMancini, Matteo
dc.contributor.authorMancke, Falk
dc.contributor.authorMånsson, Kristoffer N. T.
dc.contributor.authorManuck, Stephen B.
dc.contributor.authorMather, Mara
dc.contributor.authorMeeten, Frances
dc.contributor.authorMin, Jungwon
dc.contributor.authorMueller, Bryon A.
dc.contributor.authorMuench, Vera
dc.contributor.authorNees, Frauke
dc.contributor.authorNga, Lin
dc.contributor.authorNilsonne, Gustav
dc.contributor.authorOrdonez Acuna, Daniela
dc.contributor.authorOsnes, Berge
dc.contributor.authorOttaviani, Cristina
dc.contributor.authorPenninx, Brenda W J H
dc.contributor.authorPonzio, Allison
dc.contributor.authorPoudel, Govinda R.
dc.contributor.authorReinelt, Janis
dc.contributor.authorRen, Ping
dc.contributor.authorSakaki, Michiko
dc.contributor.authorSchumann, Andy
dc.contributor.authorSørensen, Lin
dc.contributor.authorSpecht, Karsten
dc.contributor.authorStraub, Joana
dc.contributor.authorTamm, Sandra
dc.contributor.authorThai, Michelle
dc.contributor.authorThayer, Julian F.
dc.contributor.authorUbani, Benjamin
dc.contributor.authorvan der Mee, Denise J.
dc.contributor.authorvan Velzen, Laura S.
dc.contributor.authorVentura‐Bort, Carlos
dc.contributor.authorVillringer, Arno
dc.contributor.authorWatson, David R.
dc.contributor.authorWei, Luqing
dc.contributor.authorWendt, Julia
dc.contributor.authorWestlund Schreiner, Melinda
dc.contributor.authorWestlye, Lars Tjelta
dc.contributor.authorWeymar, Mathias
dc.contributor.authorWinkelmann, Tobias
dc.contributor.authorWu, Guo‐Rong
dc.contributor.authorYoo, Hyun Joo
dc.contributor.authorQuintana, Daniel
dc.description.abstractUnderstanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting‐state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies may be due to sex and age differences in HR/HRV and CT. Previous studies have been limited by small sample sizes, which impede the assessment of sex differences and aging effects on the association between ANS function and CT. To overcome these limitations, 20 groups worldwide contributed data collected under similar protocols of CT assessment and HR/HRV recording to be pooled in a mega‐analysis (N = 1,218 (50.5% female), mean age 36.7 years (range: 12–87)). Findings suggest a decline in HRV as well as CT with increasing age. CT, particularly in the orbitofrontal cortex, explained additional variance in HRV, beyond the effects of aging. This pattern of results may suggest that the decline in HRV with increasing age is related to a decline in orbitofrontal CT. These effects were independent of sex and specific to HRV; with no significant association between CT and HR. Greater CT across the adult lifespan may be vital for the maintenance of healthy cardiac regulation via the ANS—or greater cardiac vagal activity as indirectly reflected in HRV may slow brain atrophy. Findings reveal an important association between CT and cardiac parasympathetic activity with implications for healthy aging and longevity that should be studied further in longitudinal research.en_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.titleCortical thickness and resting‐state cardiac function across the lifespan: A cross‐sectional pooled mega‐analysisen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2020 The Authorsen_US
dc.identifier.citationPsychophysiology. 2020en_US

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Navngivelse-Ikkekommersiell 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse-Ikkekommersiell 4.0 Internasjonal