Show simple item record

dc.contributor.authorErchinger, Vera Jane
dc.contributor.authorMiller, Jeremy
dc.contributor.authorJones, Thomas
dc.contributor.authorKessler, Ute
dc.contributor.authorBustillo, Juan R.
dc.contributor.authorHaavik, Jan
dc.contributor.authorPetrillo, Jonathan
dc.contributor.authorZiomek, Gregory
dc.contributor.authorHammar, Åsa
dc.contributor.authorØdegaard, Ketil Joachim
dc.contributor.authorCalhoun, Vince D.
dc.contributor.authorMcClintock, Shawn M.
dc.contributor.authorErsland, Lars
dc.contributor.authorOltedal, Leif
dc.contributor.authorAbbott, Christopher
dc.PublishedBrain and Behavior. 2020, 1-11.
dc.description.abstractObjective The anticonvulsant hypothesis posits that ECT’s mechanism of action is related to enhancement of endogenous anticonvulsant brain mechanisms. Results of prior studies investigating the role of the inhibitory neurotransmitter gamma‐aminobutyric acid (“GABA+”, GABA and coedited macromolecules) in the pathophysiology and treatment of depression remain inconclusive. The aim of our study was to investigate treatment‐responsive changes of GABA+ in subjects with a depressive episode receiving electroconvulsive therapy (ECT). Methods In total, 41 depressed subjects (DEP) and 35 healthy controls (HC) were recruited at two independent sites in Norway and the USA. MEGA‐PRESS was used for investigation of GABA+ in the anterior cingulate cortex. We assessed longitudinal and cross‐sectional differences between DEP and HC, as well as the relationship between GABA+ change and change in depression severity and number of ECTs. We also assessed longitudinal differences in cognitive performance and GABA+ levels. Results Depressive episode did not show a difference in GABA+ relative to HC (t71 = −0.36, p = .72) or in longitudinal analysis (t36 = 0.97, p = .34). Remitters and nonremitters did not show longitudinal (t36 = 1.12, p = .27) or cross‐sectional differences in GABA+. GABA+ levels were not related to changes in antidepressant response (t35 = 1.12, p = .27) or treatment number (t36 = 0.05, p = .96). An association between cognitive performance and GABA+ levels was found in DEP that completed cognitive effortful testing (t18 = 2.4, p = .03). Conclusion Our results failed to support GABA as a marker for depression and abnormal mood state and provide no support for the anticonvulsant hypothesis of ECT. ECT‐induced change in GABA concentrations may be related to change in cognitive function.en_US
dc.publisherWiley Open Accessen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleAnterior cingulate gamma-aminobutyric acid concentrations and electroconvulsive therapyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2020 The Authorsen_US
dc.source.journalBrain and Behavioren_US
dc.identifier.citationBrain and Behavior. 2020;10(11):e01833en_US

Files in this item


This item appears in the following Collection(s)

Show simple item record

Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal