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dc.contributor.authorLee, Yunsung
dc.contributor.authorLøkås Haftorn, Kristine
dc.contributor.authorDenault, William Robert Paul
dc.contributor.authorNustad, Haakon Egdetveit
dc.contributor.authorPage, Christian
dc.contributor.authorMoen, Gunn-Helen
dc.contributor.authorMagnus, Maria C.
dc.contributor.authorGjessing, Håkon K.
dc.contributor.authorHarris, Jennifer R.
dc.contributor.authorMagnus, Per
dc.contributor.authorHåberg, Siri E.
dc.contributor.authorJugessur, Astanand
dc.contributor.authorBohlin, Jon
dc.contributor.authorLyle, Robert
dc.contributor.authorLee-Ødegård, Sindre
dc.contributor.authorGroop, Leif C.
dc.contributor.authorPrasad, Rashmi B.
dc.contributor.authorSletner, Line
dc.contributor.authorSommer, Christine
dc.PublishedBMC Genomics. 2020, 21 (1), .
dc.description.abstractBackground Epigenetic clocks have been recognized for their precise prediction of chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks are based on CpGs from the Illumina HumanMethylation450 BeadChip (450 K) which has now been replaced by the latest platform, Illumina MethylationEPIC BeadChip (EPIC). Thus, it remains unclear to what extent EPIC contributes to increased precision and accuracy in the prediction of chronological age. Results We developed three blood-based epigenetic clocks for human adults using EPIC-based DNA methylation (DNAm) data from the Norwegian Mother, Father and Child Cohort Study (MoBa) and the Gene Expression Omnibus (GEO) public repository: 1) an Adult Blood-based EPIC Clock (ABEC) trained on DNAm data from MoBa (n = 1592, age-span: 19 to 59 years), 2) an extended ABEC (eABEC) trained on DNAm data from MoBa and GEO (n = 2227, age-span: 18 to 88 years), and 3) a common ABEC (cABEC) trained on the same training set as eABEC but restricted to CpGs common to 450 K and EPIC. Our clocks showed high precision (Pearson correlation between chronological and epigenetic age (r) > 0.94) in independent cohorts, including GSE111165 (n = 15), GSE115278 (n = 108), GSE132203 (n = 795), and the Epigenetics in Pregnancy (EPIPREG) study of the STORK Groruddalen Cohort (n = 470). This high precision is unlikely due to the use of EPIC, but rather due to the large sample size of the training set. Conclusions Our ABECs predicted adults’ chronological age precisely in independent cohorts. As EPIC is now the dominant platform for measuring DNAm, these clocks will be useful in further predictions of chronological age, age-related diseases, and mortality.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleBlood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC arrayen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2020 The Author(s).en_US
dc.source.journalBMC Genomicsen_US
dc.identifier.citationBMC Genomics. 2020, 21, 747en_US

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