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dc.contributor.authorSævik, Fredrik Bjorvatn
dc.contributor.authorEriksen, Ragnar
dc.contributor.authorEide, Geir Egil
dc.contributor.authorGilja, Odd Helge
dc.contributor.authorNylund, Kim
dc.date.accessioned2021-05-03T10:59:10Z
dc.date.available2021-05-03T10:59:10Z
dc.date.created2020-11-25T09:35:12Z
dc.date.issued2020-06-06
dc.identifier.issn1873-9946
dc.identifier.urihttps://hdl.handle.net/11250/2753218
dc.description.abstractBackground and Aims To improve management of patients with Crohn’s disease, objective measurements of disease activity are needed. Ileocolonoscopy is the current reference standard but has limitations that restrict repeated use. Ultrasonography is potentially useful for activity monitoring, but no validated sonographic activity index is currently in widespread use. Thus, we aimed to construct and validate a simple ultrasound score for Crohn’s disease. Methods Forty patients were prospectively examined with ultrasound and endoscopy in the development phase. The Simple Endoscopic Score for Crohn’s Disease [SES-CD] was used as a reference standard. Seven ultrasound variables [bowel wall thickness, length, colour Doppler, stenosis, fistula, stratification and fatty wrapping] were initially included, and multiple linear regression was used to select the variables that should be included in the final score. Second, the ultrasound data from each patient were re-examined for interobserver assessment using weighted kappa and intraclass correlation. Finally, the activity index was validated in a new cohort of 124 patients. Results Length, fistula and stenosis were excluded. The combination of the remaining variables provided a multiple correlation coefficient of r = 0.78. Interobserver analysis revealed poor agreement for stratification and fatty wrapping and these were thus excluded. There was excellent interobserver agreement for the remaining score consisting of wall thickness and colour Doppler. In both patient cohorts, the ultrasound score correlated well with SES-CD [Development cohort: rho = 0.83, p < 0.001, Validation cohort: rho = 0.78, p < 0.001]. A receiver operating characteristic curve analysis revealed an area under the curve of 0.92 and 0.88 for detecting endoscopic activity and moderate endoscopic activity, respectively. Conclusions A simple ultrasound activity index for Crohn’s disease consisting of bowel wall thickness and colour Doppler was constructed and validated and correlated well with endoscopic disease activity.en_US
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleDevelopment and Validation of a Simple Ultrasound Activity Score for Crohn’s Diseaseen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright The Author(s) 2020en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.doi10.1093/ecco-jcc/jjaa112
dc.identifier.cristin1852021
dc.source.journalJournal of Crohn's and colitisen_US
dc.source.pagenumber115–124en_US
dc.identifier.citationJournal of Crohn's and Colitis. 2021, 15 (1), 115–124en_US
dc.source.volume15en_US
dc.source.issue1en_US


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