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dc.contributor.authorTrieu, Mai Chi
dc.contributor.authorBansal, Amit
dc.contributor.authorMadsen, Anders
dc.contributor.authorZhou, Fan
dc.contributor.authorSævik, Marianne
dc.contributor.authorVahokoski, Juha
dc.contributor.authorBrokstad, Karl Albert
dc.contributor.authorKrammer, Florian
dc.contributor.authorTøndel, Camilla
dc.contributor.authorMohn, Kristin Greve Isdahl
dc.contributor.authorBlomberg, Bjørn
dc.contributor.authorLangeland, Nina
dc.contributor.authorCox, Rebecca Jane
dc.date.accessioned2021-05-14T08:03:19Z
dc.date.available2021-05-14T08:03:19Z
dc.date.created2020-11-29T09:17:32Z
dc.date.issued2021
dc.identifier.issn0022-1899
dc.identifier.urihttps://hdl.handle.net/11250/2755253
dc.description.abstractBackground During the coronavirus disease 2019 (COVID-19) pandemic, many countries experienced infection in health care workers (HCW) due to overburdened health care systems. Whether infected HCW acquire protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unclear. Methods In a Norwegian prospective cohort study, we enrolled 607 HCW before and after the first COVID-19 wave. Exposure history, COVID-19–like symptoms, and serum samples were collected. SARS-CoV-2–specific antibodies were characterized by spike-protein IgG/IgM/IgA enzyme-linked immunosorbent and live-virus neutralization assays. Results Spike-specific IgG/IgM/IgA antibodies increased after the first wave in HCW with, but not in HCW without, COVID-19 patient exposure. Thirty-two HCW (5.3%) had spike-specific antibodies (11 seroconverted with ≥4-fold increase, 21 were seropositive at baseline). Neutralizing antibodies were found in 11 HCW that seroconverted, of whom 4 (36.4%) were asymptomatic. Ninety-seven HCW were tested by reverse transcriptase polymerase chain reaction (RT-PCR) during follow-up; 8 were positive (7 seroconverted, 1 had undetectable antibodies). Conclusions We found increases in SARS-CoV-2 neutralizing antibodies in infected HCW, especially after COVID-19 patient exposure. Our data show a low number of SARS-CoV-2–seropositive HCW in a low-prevalence setting; however, the proportion of seropositivity was higher than RT-PCR positivity, highlighting the importance of antibody testing.en_US
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titleSARS-CoV-2–Specific Neutralizing Antibody Responses in Norwegian Health Care Workers After the First Wave of COVID-19 Pandemic: A Prospective Cohort Studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright The Author(s) 2020en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.doi10.1093/infdis/jiaa737
dc.identifier.cristin1853723
dc.source.journalJournal of Infectious Diseasesen_US
dc.source.pagenumber589-599en_US
dc.identifier.citationJournal of Infectious Diseases. 2021, 223 (4), 589-599.en_US
dc.source.volume223en_US
dc.source.issue4en_US


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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