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dc.contributor.authorSköld, Camilla
dc.contributor.authorBjørge, Tone
dc.contributor.authorEkbom, Anders
dc.contributor.authorEngeland, Anders
dc.contributor.authorGissler, Mika
dc.contributor.authorGrotmol, Tom
dc.contributor.authorMadanat-Harjuoja, Laura-Maria
dc.contributor.authorOrding, Anne Gulbech
dc.contributor.authorTrabert, Britton
dc.contributor.authorTretli, Steinar
dc.contributor.authorTroisi, Rebecca
dc.contributor.authorSørensen, Henrik Toft
dc.contributor.authorGlimelius, Ingrid
dc.description.abstractBackground Non-epithelial ovarian cancers are divided into sex cord-stromal tumours (SCSTs) and germ cell tumours (GCTs). Whereas parity and other pregnancy-related factors are protective for epithelial ovarian cancer, their associations with SCSTs and GCTs remains unclear. Methods Using data from the medical birth registries from Denmark, Finland, Norway and Sweden, we compared all parous women with a diagnosis of SCSTs (n = 420) or GCTs (n = 345) 1970–2013 with up to 10 parous controls (SCSTs n = 4041; GCTs n = 2942) matched on the cases’ birth year and country. We used conditional logistic regression to estimate odds ratios (ORs) with 95% confidence intervals (CIs) of associations between pregnancy-related factors and SCSTs and GCTs. Results The risk of SCSTs, but not GCTs, decreased with higher age at last birth [≥40 versus <25 years: OR 0.48 (95% CI 0.23–0.98)]. The risk of SCSTs (but not GCTs) also decreased with shorter time since last birth. Number of births, preterm birth, preeclampsia, and offspring size were not associated with risk of SCSTs or GCTs. Conclusions We found a decreased risk of SCSTs with higher age at last birth and shorter time since last birth. The risk of SCSTs (but not GCTs) may be influenced by the woman’s reproductive history.en_US
dc.publisherSpringer Natureen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titlePregnancy-related risk factors for sex cord-stromal tumours and germ cell tumours in parous women: a registry-based studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright The Author(s) 2020en_US
dc.source.journalBritish Journal of Canceren_US
dc.identifier.citationBritish Journal of Cancer. 2020, 123, 161-166.en_US

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