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dc.contributor.authorPeralta, Gabriela P.
dc.contributor.authorMarcon, Alessandro
dc.contributor.authorCarsin, Anne-Elie
dc.contributor.authorAbramson, Michael J.
dc.contributor.authorAccordini, Simone
dc.contributor.authorAmaral, André F.S.
dc.contributor.authorAntó, Josep Maria
dc.contributor.authorBowatte, Gayan
dc.contributor.authorBurney, Peter
dc.contributor.authorCorsico, Angelo
dc.contributor.authorDemoly, Pascal
dc.contributor.authorDharmage, Shyamali C.
dc.contributor.authorForsberg, Bertil
dc.contributor.authorFuertes, Elaine
dc.contributor.authorGarcia-Larsen, Vanessa
dc.contributor.authorGislason, Thorarinn
dc.contributor.authorGullón, José-Antonio
dc.contributor.authorHeinrich, Joachim
dc.contributor.authorHolm, Mathias
dc.contributor.authorJarvis, Deborah
dc.contributor.authorJanson, Christer
dc.contributor.authorJõgi, Rain
dc.contributor.authorJohannessen, Ane
dc.contributor.authorLeynaert, Bénédicte
dc.contributor.authorRovira, Jesús Martínez-Moratalla
dc.contributor.authorNowak, Dennis
dc.contributor.authorProbst-Hensch, Nicole
dc.contributor.authorRaherison, Chantal
dc.contributor.authorSánchez-Ramos, José Luis
dc.contributor.authorSigsgaard, Torben
dc.contributor.authorSiroux, Valérie
dc.contributor.authorSquillacioti, Giulia
dc.contributor.authorUrrutia, Isabel
dc.contributor.authorWeyler, Joost
dc.contributor.authorZock, Jan-Paul
dc.contributor.authorGarcia-Aymerich, Judith
dc.description.abstractBackground Previous studies have reported an association between weight increase and excess lung function decline in young adults followed for short periods. We aimed to estimate lung function trajectories during adulthood from 20-year weight change profiles using data from the population-based European Community Respiratory Health Survey (ECRHS). Methods We included 3673 participants recruited at age 20–44 years with repeated measurements of weight and lung function (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1)) in three study waves (1991–93, 1999–2003, 2010–14) until they were 39–67 years of age. We classified subjects into weight change profiles according to baseline body mass index (BMI) categories and weight change over 20 years. We estimated trajectories of lung function over time as a function of weight change profiles using population-averaged generalised estimating equations. Results In individuals with normal BMI, overweight and obesity at baseline, moderate (0.25–1 kg/year) and high weight gain (>1 kg/year) during follow-up were associated with accelerated FVC and FEV1 declines. Compared with participants with baseline normal BMI and stable weight (±0.25 kg/year), obese individuals with high weight gain during follow-up had −1011 mL (95% CI −1.259 to −763) lower estimated FVC at 65 years despite similar estimated FVC levels at 25 years. Obese individuals at baseline who lost weight (<−0.25 kg/year) exhibited an attenuation of FVC and FEV1 declines. We found no association between weight change profiles and FEV1/FVC decline. Conclusion Moderate and high weight gain over 20 years was associated with accelerated lung function decline, while weight loss was related to its attenuation. Control of weight gain is important for maintaining good lung function in adult life.en_US
dc.publisherBMJ Publishing Groupen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleBody mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright Author(s) (or their employer(s)) 2020en_US
dc.identifier.citationThorax. 2020, 75 (4), 313-320.en_US

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