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dc.contributor.authorMonsen, Anne Lise Bjørke
dc.contributor.authorVarsi, Kristin
dc.contributor.authorAverina, Maria
dc.contributor.authorBrox, Jan
dc.contributor.authorHuber, Sandra
dc.description.abstractObjectives To examine concentrations of perfluoroalkyl substances (PFASs) and lifestyle factors that may contribute to higher levels of pollutants in never-pregnant women of fertile age. Design Observational cross-sectional study. Setting Participants were recruited among employees and students at Haukeland University Hospital and the University of Bergen, Norway. Participants Healthy, never-pregnant Norwegian women (n=158) of fertile age (18–39 years). Outcomes Concentrations of 20 different PFASs, mercury (Hg), lead, cadmium, total, high-density lipoprotein and low-density lipoprotein (LDL) cholesterol, in addition to self-reported data on dietary intake. Results Seven PFASs were detected in more than 95% of the women. Women aged 30–39 years had higher concentrations of sum PFAS compared with younger women. Serum PFASs were significantly intercorrelated (rho: 0.34–0.98, p<0.001) and six of them were significantly correlated to whole blood Hg (rho: 0.21–0.74, p<0.01). Fish consumption was the strongest predictor for most serum PFASs and for whole blood Hg. Fish consumption and serum perfluorooctanesulfonic acid (PFOS) concentrations were both positively associated with serum total and LDL cholesterol, established risk factors for cardiovascular disease. Conclusions The majority of Norwegian never-pregnant women of fertile age had a mixture of seven different PFASs and Hg detected in their blood. PFAS concentrations were higher in older women and associated with fish intake. As the mean age of women at first birth is increasing, several factors require further consideration including diet, as this may influence the burden of PFAS to the next generation.en_US
dc.publisherBMJ Publishing Groupen_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.titlePerfluoroalkyl substances (PFASs) and mercury in never-pregnant women of fertile age: association with fish consumption and unfavorable lipid profileen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright Author(s) (or their employer(s)) 2020en_US
dc.source.journalBMJ Nutrition, Prevention and Healthen_US
dc.identifier.citationBMJ Nutrition, Prevention and Health. 2020, 3 (2), e000131.en_US

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Navngivelse-Ikkekommersiell 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse-Ikkekommersiell 4.0 Internasjonal