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dc.contributor.authorHonigberg, Michael C.
dc.contributor.authorRiise, Hilde Kristin Refvik
dc.contributor.authorDaltveit, Anne Kjersti
dc.contributor.authorTell, Grethe S.
dc.contributor.authorSulo, Gerhard
dc.contributor.authorIgland, Jannicke
dc.contributor.authorKlungsøyr, Kari
dc.contributor.authorScott, Nandita S.
dc.contributor.authorWood, Malissa J.
dc.contributor.authorNatarajan, Pradeep
dc.contributor.authorRich-Edwards, Janet W.
dc.date.accessioned2021-06-28T12:11:33Z
dc.date.available2021-06-28T12:11:33Z
dc.date.created2020-11-12T14:43:38Z
dc.date.issued2020
dc.PublishedHypertension. 2020, 76 (5), 1506-1513.
dc.identifier.issn0194-911X
dc.identifier.urihttps://hdl.handle.net/11250/2761654
dc.description.abstractHypertensive disorders of pregnancy (HDP) have been associated with heart failure (HF). It is unknown whether concurrent pregnancy complications (small-for-gestational-age or preterm delivery) or recurrent HDP modify HDP-associated HF risk. In this cohort study, we included Norwegian women with a first birth between 1980 and 2004. Follow-up occurred through 2009. Cox models examined gestational hypertension and preeclampsia in the first pregnancy as predictors of a composite of HF-related hospitalization or HF-related death, with assessment of effect modification by concurrent small-for-gestational-age or preterm delivery. Additional models were stratified by final parity (1 versus ≥2 births) and tested associations with recurrent HDP. Among 508 422 women, 565 experienced incident HF over a median 11.8 years of follow-up. After multivariable adjustment, gestational hypertension in the first birth was not significantly associated with HF (hazard ratio, 1.41 [95% CI, 0.84–2.35], P=0.19), whereas preeclampsia was associated with a hazard ratio of 2.00 (95% CI, 1.50–2.68, P<0.001). Among women with HDP, risks were not modified by concurrent small-for-gestational-age or preterm delivery (Pinteraction=0.42). Largest hazards of HF were observed in women whose only lifetime birth was complicated by preeclampsia and women with recurrent preeclampsia. HF risks were similar after excluding women with coronary artery disease. In summary, women with preeclampsia, especially those with one lifetime birth and those with recurrent preeclampsia, experienced increased HF risk compared to women without HDP. Further research is needed to clarify causal mechanisms.en_US
dc.language.isoengen_US
dc.publisherAmerican Heart Associationen_US
dc.titleHeart failure in women with hypertensive disorders of pregnancy: Insights from the cardiovascular disease in Norway projecten_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionacceptedVersionen_US
dc.rights.holderCopyright 2020 American Heart Associationen_US
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2
dc.identifier.doi10.1161/HYPERTENSIONAHA.120.15654
dc.identifier.cristin1847439
dc.source.journalHypertensionen_US
dc.source.4076
dc.source.145
dc.source.pagenumber1506-1513en_US
dc.relation.projectEU/833076en_US
dc.identifier.citationHypertension. 2020, 76:1506–1513en_US
dc.source.volume76en_US


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