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dc.contributor.authorKuiper, Ingrid Nordeide
dc.contributor.authorSvanes, Cecilie
dc.contributor.authorMarkevych, Iana
dc.contributor.authorAccordini, Simone
dc.contributor.authorBertelsen, Randi Jacobsen
dc.contributor.authorBråbäck, Lennart
dc.contributor.authorChristensen, Jesper Heile
dc.contributor.authorForsberg, Bertil
dc.contributor.authorHalvorsen, Thomas
dc.contributor.authorHeinrich, Joachim
dc.contributor.authorHertel, Ole
dc.contributor.authorHoek, Gerard
dc.contributor.authorHolm, Mathias
dc.contributor.authorDe Hoogh, Kees
dc.contributor.authorJanson, Christer
dc.contributor.authorMalinovschi, Andrei
dc.contributor.authorMarcon, Alessandro
dc.contributor.authorNilsen, Roy Miodini
dc.contributor.authorSigsgaard, Torben
dc.contributor.authorJohannessen, Ane
dc.description.abstractObjectives To investigate if air pollution and greenness exposure from birth till adulthood affects adult asthma, rhinitis and lung function. Methods: We analysed data from 3428 participants (mean age 28) in the RHINESSA study in Norway and Sweden. Individual mean annual residential exposures to nitrogen dioxide (NO2), particulate matter (PM10 and PM2.5), black carbon (BC), ozone (O3) and greenness (normalized difference vegetation index (NDVI)) were averaged across susceptibility windows (0–10 years, 10–18 years, lifetime, adulthood (year before study participation)) and analysed in relation to physician diagnosed asthma (ever/allergic/non-allergic), asthma attack last 12 months, current rhinitis and low lung function (lower limit of normal (LLN), z-scores of forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and FEV1/FVC below 1.64). We performed logistic regression for asthma attack, rhinitis and LLN lung function (clustered with family and study centre), and conditional logistic regression with a matched case-control design for ever/allergic/non-allergic asthma. Multivariable models were adjusted for parental asthma and education. Results: Childhood, adolescence and adult exposure to NO2, PM10 and O3 were associated with an increased risk of asthma attacks (ORs between 1.29 and 2.25), but not with physician diagnosed asthma. For rhinitis, adulthood exposures seemed to be most important. Childhood and adolescence exposures to PM2.5 and O3 were associated with lower lung function, in particular FEV1 (range ORs 2.65 to 4.21). No associations between NDVI and asthma or rhinitis were revealed, but increased NDVI was associated with lower FEV1 and FVC in all susceptibility windows (range ORs 1.39 to 1.74). Conclusions: Air pollution exposures in childhood, adolescence and adulthood were associated with increased risk of asthma attacks, rhinitis and low lung function in adulthood. Greenness was not associated with asthma or rhinitis, but was a risk factor for low lung function.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleLifelong exposure to air pollution and greenness in relation to asthma, rhinitis and lung function in adulthooden_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2020 The Authors.en_US
dc.source.journalEnvironment Internationalen_US
dc.identifier.citationEnvironment International. 2021, 146, 106219en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal