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dc.contributor.authorBeresniewicz, Justyna
dc.contributor.authorCraven, Alexander R.
dc.contributor.authorHugdahl, Kenneth
dc.contributor.authorLøberg, Else-Marie
dc.contributor.authorKroken, Rune Andreas
dc.contributor.authorJohnsen, Erik
dc.contributor.authorGruner, Eli Renate
dc.description.abstractThe relation between auditory verbal hallucinations (AVH) and white matter has been studied, but results are still inconsistent. This inconsistency may be related to having only a single time-point of AVH assessment in many studies, not capturing that AVH severity fluctuates over time. In the current study, AVH fluctuations were captured by utilizing a longitudinal design and using repeated (Positive and Negative Symptoms Scale) PANSS questionnaire interviews over a 12 month period. We used a Magnetic Resonance Diffusion Tensor Imaging (MR DTI) sequence and tract-based spatial statistics (TBSS) to explore white matter differences between two subtypes of schizophrenia patients; 44 hallucinating (AVH+) and 13 non-hallucinating (AVH-), compared to 13 AVH- matched controls and 44 AVH+ matched controls. Additionally, we tested for hemispheric fractional anisotropy (FA) asymmetry between the groups. Significant widespread FA-value reduction was found in the AVH+ group in comparison to the AVH- group. Although not significant, the extracted FA-values for the control group were in between the two patient groups, for all clusters. We also found a significant difference in FA-asymmetry between the AVH+ and AVH- groups in two clusters, with significantly higher leftward asymmetry in the AVH- group. The current findings suggest a possible qualitative difference in white matter integrity between AVH+ and AVH- patients. Strengths and limitations of the study are discussed.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleWhite matter microstructural differences between hallucinating and non-hallucinating schizophrenia spectrum patientsen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2021 by the Authorsen_US
dc.source.journalDiagnostics (Basel)en_US
dc.identifier.citationDiagnostics (Basel). 2021, 11(1), 139en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal