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dc.contributor.authorBeresniewicz, Justyna
dc.contributor.authorCraig-Craven, Alexander Richard
dc.contributor.authorHugdahl, Kenneth
dc.contributor.authorLøberg, Else-Marie
dc.contributor.authorKroken, Rune Andreas
dc.contributor.authorJohnsen, Erik
dc.contributor.authorGruner, Eli Renate
dc.date.accessioned2021-06-30T12:59:59Z
dc.date.available2021-06-30T12:59:59Z
dc.date.created2021-01-20T14:41:57Z
dc.date.issued2021
dc.identifier.issn2075-4418
dc.identifier.urihttps://hdl.handle.net/11250/2762604
dc.description.abstractThe relation between auditory verbal hallucinations (AVH) and white matter has been studied, but results are still inconsistent. This inconsistency may be related to having only a single time-point of AVH assessment in many studies, not capturing that AVH severity fluctuates over time. In the current study, AVH fluctuations were captured by utilizing a longitudinal design and using repeated (Positive and Negative Symptoms Scale) PANSS questionnaire interviews over a 12 month period. We used a Magnetic Resonance Diffusion Tensor Imaging (MR DTI) sequence and tract-based spatial statistics (TBSS) to explore white matter differences between two subtypes of schizophrenia patients; 44 hallucinating (AVH+) and 13 non-hallucinating (AVH-), compared to 13 AVH- matched controls and 44 AVH+ matched controls. Additionally, we tested for hemispheric fractional anisotropy (FA) asymmetry between the groups. Significant widespread FA-value reduction was found in the AVH+ group in comparison to the AVH- group. Although not significant, the extracted FA-values for the control group were in between the two patient groups, for all clusters. We also found a significant difference in FA-asymmetry between the AVH+ and AVH- groups in two clusters, with significantly higher leftward asymmetry in the AVH- group. The current findings suggest a possible qualitative difference in white matter integrity between AVH+ and AVH- patients. Strengths and limitations of the study are discussed.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleWhite matter microstructural differences between hallucinating and non-hallucinating schizophrenia spectrum patientsen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2021 by the Authorsen_US
dc.source.articlenumber139en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.3390/diagnostics11010139
dc.identifier.cristin1875648
dc.source.journalDiagnostics (Basel)en_US
dc.identifier.citationDiagnostics (Basel). 2021, 11(1), 139en_US
dc.source.volume11en_US
dc.source.issue1en_US


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