dc.contributor.author | Beresniewicz, Justyna | |
dc.contributor.author | Craven, Alexander R. | |
dc.contributor.author | Hugdahl, Kenneth | |
dc.contributor.author | Løberg, Else-Marie | |
dc.contributor.author | Kroken, Rune Andreas | |
dc.contributor.author | Johnsen, Erik | |
dc.contributor.author | Gruner, Eli Renate | |
dc.date.accessioned | 2021-06-30T12:59:59Z | |
dc.date.available | 2021-06-30T12:59:59Z | |
dc.date.created | 2021-01-20T14:41:57Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2075-4418 | |
dc.identifier.uri | https://hdl.handle.net/11250/2762604 | |
dc.description.abstract | The relation between auditory verbal hallucinations (AVH) and white matter has been studied, but results are still inconsistent. This inconsistency may be related to having only a single time-point of AVH assessment in many studies, not capturing that AVH severity fluctuates over time. In the current study, AVH fluctuations were captured by utilizing a longitudinal design and using repeated (Positive and Negative Symptoms Scale) PANSS questionnaire interviews over a 12 month period. We used a Magnetic Resonance Diffusion Tensor Imaging (MR DTI) sequence and tract-based spatial statistics (TBSS) to explore white matter differences between two subtypes of schizophrenia patients; 44 hallucinating (AVH+) and 13 non-hallucinating (AVH-), compared to 13 AVH- matched controls and 44 AVH+ matched controls. Additionally, we tested for hemispheric fractional anisotropy (FA) asymmetry between the groups. Significant widespread FA-value reduction was found in the AVH+ group in comparison to the AVH- group. Although not significant, the extracted FA-values for the control group were in between the two patient groups, for all clusters. We also found a significant difference in FA-asymmetry between the AVH+ and AVH- groups in two clusters, with significantly higher leftward asymmetry in the AVH- group. The current findings suggest a possible qualitative difference in white matter integrity between AVH+ and AVH- patients. Strengths and limitations of the study are discussed. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | White matter microstructural differences between hallucinating and non-hallucinating schizophrenia spectrum patients | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2021 by the Authors | en_US |
dc.source.articlenumber | 139 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.3390/diagnostics11010139 | |
dc.identifier.cristin | 1875648 | |
dc.source.journal | Diagnostics (Basel) | en_US |
dc.identifier.citation | Diagnostics (Basel). 2021, 11(1), 139 | en_US |
dc.source.volume | 11 | en_US |
dc.source.issue | 1 | en_US |