dc.contributor.author | Accordini, Simone | |
dc.contributor.author | Calciano, Lucia | |
dc.contributor.author | Marcon, Alessandro | |
dc.contributor.author | Pesce, Giancarlo | |
dc.contributor.author | Antó, Josep M. | |
dc.contributor.author | Beckmeyer-Borowko, Anna B. | |
dc.contributor.author | Carsin, Anne-Elie | |
dc.contributor.author | Corsico, Angelo G. | |
dc.contributor.author | Imboden, Medea | |
dc.contributor.author | Janson, Christer | |
dc.contributor.author | Keidel, Dirk | |
dc.contributor.author | Locatelli, Francesca | |
dc.contributor.author | Svanes, Cecilie | |
dc.contributor.author | Burney, Peter G.J. | |
dc.contributor.author | Jarvis, Deborah L. | |
dc.contributor.author | Probst-Hensch, Nicole M. | |
dc.contributor.author | Minelli, Cosetta | |
dc.date.accessioned | 2021-07-02T08:24:39Z | |
dc.date.available | 2021-07-02T08:24:39Z | |
dc.date.created | 2020-06-09T13:49:58Z | |
dc.date.issued | 2020 | |
dc.Published | Scientific Reports. 2020, 10:3452 1-9. | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://hdl.handle.net/11250/2763043 | |
dc.description.abstract | Investigating COPD trends may help healthcare providers to forecast future disease burden. We estimated sex- and smoking-specific incidence trends of pre-bronchodilator airflow obstruction (AO) among adults without asthma from 11 European countries within a 20-year follow-up (ECRHS and SAPALDIA cohorts). We also quantified the extent of misclassification in the definition based on pre-bronchodilator spirometry (using post-bronchodilator measurements from a subsample of subjects) and we used this information to estimate the incidence of post-bronchodilator AO (AOpost-BD), which is the primary characteristic of COPD. AO incidence was 4.4 (95% CI: 3.5–5.3) male and 3.8 (3.1–4.6) female cases/1,000/year. Among ever smokers (median pack-years: 20, males; 12, females), AO incidence significantly increased with ageing in men only [incidence rate ratio (IRR), 1-year increase: 1.05 (1.03–1.07)]. A strong exposure-response relationship with smoking was found both in males [IRR, 1-pack-year increase: 1.03 (1.02–1.04)] and females [1.03 (1.02–1.05)]. The positive predictive value of AO for AOpost-BD was 59.1% (52.0–66.2%) in men and 42.6% (35.1–50.1%) in women. AOpost-BD incidence was 2.6 (1.7–3.4) male and 1.6 (1.0–2.2) female cases/1,000/year. AO incidence was considerable in Europe and the sex-specific ageing-related increase among ever smokers was strongly related to cumulative tobacco exposure. AOpost-BD incidence is expected to be half of AO incidence. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Nature Research | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright the authors 2020 | en_US |
dc.source.articlenumber | 3452 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1038/s41598-020-60478-5 | |
dc.identifier.cristin | 1814560 | |
dc.source.journal | Scientific Reports | en_US |
dc.source.40 | 10:3452 | |
dc.identifier.citation | Scientific Reports. 2020, 10, 3452. | en_US |
dc.source.volume | 10 | en_US |