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dc.contributor.authorAccordini, Simone
dc.contributor.authorCalciano, Lucia
dc.contributor.authorMarcon, Alessandro
dc.contributor.authorPesce, Giancarlo
dc.contributor.authorAntó, Josep M.
dc.contributor.authorBeckmeyer-Borowko, Anna B.
dc.contributor.authorCarsin, Anne-Elie
dc.contributor.authorCorsico, Angelo G.
dc.contributor.authorImboden, Medea
dc.contributor.authorJanson, Christer
dc.contributor.authorKeidel, Dirk
dc.contributor.authorLocatelli, Francesca
dc.contributor.authorSvanes, Cecilie
dc.contributor.authorBurney, Peter G.J.
dc.contributor.authorJarvis, Deborah L.
dc.contributor.authorProbst-Hensch, Nicole M.
dc.contributor.authorMinelli, Cosetta
dc.PublishedScientific Reports. 2020, 10:3452 1-9.
dc.description.abstractInvestigating COPD trends may help healthcare providers to forecast future disease burden. We estimated sex- and smoking-specific incidence trends of pre-bronchodilator airflow obstruction (AO) among adults without asthma from 11 European countries within a 20-year follow-up (ECRHS and SAPALDIA cohorts). We also quantified the extent of misclassification in the definition based on pre-bronchodilator spirometry (using post-bronchodilator measurements from a subsample of subjects) and we used this information to estimate the incidence of post-bronchodilator AO (AOpost-BD), which is the primary characteristic of COPD. AO incidence was 4.4 (95% CI: 3.5–5.3) male and 3.8 (3.1–4.6) female cases/1,000/year. Among ever smokers (median pack-years: 20, males; 12, females), AO incidence significantly increased with ageing in men only [incidence rate ratio (IRR), 1-year increase: 1.05 (1.03–1.07)]. A strong exposure-response relationship with smoking was found both in males [IRR, 1-pack-year increase: 1.03 (1.02–1.04)] and females [1.03 (1.02–1.05)]. The positive predictive value of AO for AOpost-BD was 59.1% (52.0–66.2%) in men and 42.6% (35.1–50.1%) in women. AOpost-BD incidence was 2.6 (1.7–3.4) male and 1.6 (1.0–2.2) female cases/1,000/year. AO incidence was considerable in Europe and the sex-specific ageing-related increase among ever smokers was strongly related to cumulative tobacco exposure. AOpost-BD incidence is expected to be half of AO incidence.en_US
dc.publisherNature Researchen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleIncidence trends of airflow obstruction among European adults without asthma: a 20-year cohort studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright the authors 2020en_US
dc.source.journalScientific Reportsen_US
dc.identifier.citationScientific Reports. 2020, 10, 3452.en_US

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