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dc.contributor.authorKnudsen, Gerd Toril Mørkve
dc.contributor.authorDharmage, Shyamali C.
dc.contributor.authorJanson, Christer
dc.contributor.authorAbramson, Michael J.
dc.contributor.authorBenediktsdóttir, Bryndís
dc.contributor.authorMalinovschi, Andrei
dc.contributor.authorSkulstad, Svein Magne
dc.contributor.authorBertelsen, Randi Jacobsen
dc.contributor.authorReal, Francisco Gomez
dc.contributor.authorSchlünssen, Vivi
dc.contributor.authorJögi, Nils Oskar
dc.contributor.authorSánchez-Ramos, José Luis
dc.contributor.authorHolm, Mathias
dc.contributor.authorGarcia-Aymerich, Judith
dc.contributor.authorForsberg, Bertil
dc.contributor.authorSvanes, Cecilie
dc.contributor.authorJohannessen, Ane
dc.PublishedPLOS ONE. 2020, 15:e0235632 (7), 1-20.
dc.description.abstractEmerging evidence suggests that parents’ preconception exposures may influence offspring health. We aimed to investigate maternal and paternal smoking onset in specific time windows in relation to offspring body mass index (BMI) and fat mass index (FMI). We investigated fathers (n = 2111) and mothers (n = 2569) aged 39–65 years, of the population based RHINE and ECRHS studies, and their offspring aged 18–49 years (n = 6487, mean age 29.6 years) who participated in the RHINESSA study. BMI was calculated from self-reported height and weight, and FMI was estimated from bioelectrical impedance measures in a subsample. Associations with parental smoking were analysed with generalized linear regression adjusting for parental education and clustering by study centre and family. Interactions between offspring sex were analysed, as was mediation by parental pack years, parental BMI, offspring smoking and offspring birthweight. Fathers’ smoking onset before conception of the offspring (onset ≥15 years) was associated with higher BMI in the offspring when adult (β 0.551, 95%CI: 0.174–0.929, p = 0.004). Mothers’ preconception and postnatal smoking onset was associated with higher offspring BMI (onset <15 years: β1.161, 95%CI 0.378–1.944; onset ≥15 years: β0.720, 95%CI 0.293–1.147; onset after offspring birth: β2.257, 95%CI 1.220–3.294). However, mediation analysis indicated that these effects were fully mediated by parents’ postnatal pack years, and partially mediated by parents’ BMI and offspring smoking. Regarding FMI, sons of smoking fathers also had higher fat mass (onset <15 years β1.604, 95%CI 0.269–2.939; onset ≥15 years β2.590, 95%CI 0.544–4.636; and onset after birth β2.736, 95%CI 0.621–4.851). There was no association between maternal smoking and offspring fat mass. We found that parents’ smoking before conception was associated with higher BMI in offspring when they reached adulthood, but that these effects were mediated through parents’ pack years, suggesting that cumulative smoking exposure during offspring’s childhood may elicit long lasting effects on offspring BMI.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleParents’ smoking onset before conception as related to body mass index and fat mass in adult offspring: Findings from the RHINESSA generation studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright the authors 2020en_US
dc.source.journalPLOS ONEen_US
dc.identifier.citationPLoS ONE. 2020, 15 (7), e0235632.en_US

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