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dc.contributor.authorTollånes, Mette Christophersen
dc.contributor.authorKran, Anne-Marte Bakken
dc.contributor.authorAbildsnes, Eirik
dc.contributor.authorJenum, Pål
dc.contributor.authorBreivik, Anne Christin
dc.contributor.authorSandberg, Sverre
dc.date.accessioned2021-07-07T08:59:44Z
dc.date.available2021-07-07T08:59:44Z
dc.date.created2020-10-05T17:24:56Z
dc.date.issued2020
dc.PublishedClinical Chemistry and Laboratory Medicine. 2020, 58 (9), 1595-1600.
dc.identifier.issn1434-6621
dc.identifier.urihttps://hdl.handle.net/11250/2763685
dc.description.abstractObjectives: SARS-CoV-2, causing COVID-19, has emerged to cause a human pandemic. Detection of SARS-CoV-2 in respiratory samples by using PCR is the standard laboratory diagnostic tool. Our aim was to perform a limited evaluation of the diagnostic performance and user-friendliness of eleven rapid tests for detection of antibodies against SARS-CoV-2. Methods: All participants were tested with PCR against SARS-CoV-2 at a clinical microbiology laboratory. Comparing with results from PCR tests, we evaluated the rapid tests’ performances in three arms; 1) 20 hospitalized patients with PCR-confirmed COVID-19, 2) 23 recovered outpatients with former PCR-confirmed COVID-19, and 3) 49 participants with suspected COVID-19 presenting at a primary care emergency room. Results: All eleven tests detected antibodies in hospitalized COVID-19 patients, though with varying sensitivities. In former outpatients recovered from COVID-19, there were differences between tests in the immunoglobulin type G (IgG) sensitivity, with five tests having a sensitivity below 65%. In participants with suspected COVID-19 infection, the rapid tests had very low sensitivities. Most rapid tests were easy to perform and interpret. Conclusions: Rapid tests were not suited as stand-alone tests to detect present infection in a Norwegian primary care emergency room population. All the rapid tests were able to detect SARS-CoV-2 antibodies, although sensitivities varied and were generally higher in the study arm of more severely affected participants. Rapid tests with high IgG sensitivity (and specificity) may be useful for confirmation of past infection. An independent evaluation should be performed in the intended population before introducing a rapid test.en_US
dc.language.isoengen_US
dc.publisherDe Gruyteren_US
dc.titleEvaluation of eleven rapid tests for detection of antibodies against SARS-CoV-2en_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2020 Walter de Gruyteren_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1515/cclm-2020-0628
dc.identifier.cristin1837306
dc.source.journalClinical Chemistry and Laboratory Medicineen_US
dc.source.4058
dc.source.149
dc.source.pagenumber1595-1600en_US
dc.identifier.citationClinical Chemistry and Laboratory Medicine. 2020, 58 (9), 1595-1600.en_US
dc.source.volume58en_US
dc.source.issue9en_US


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