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dc.contributor.authorMartin-Duran, José M.
dc.contributor.authorVellutini, Bruno Cossermelli
dc.contributor.authorMarletaz, Ferdinand
dc.contributor.authorCetrangolo, Viviana
dc.contributor.authorCvetesic, Nevena
dc.contributor.authorThiel, Daniel
dc.contributor.authorHenriet, Simon
dc.contributor.authorGrau-Bové, Xavier
dc.contributor.authorCarrillo-Baltodano, Allan M.
dc.contributor.authorGu, Wenjia
dc.contributor.authorKerbl, Alexandra
dc.contributor.authorMarquez, Yamile
dc.contributor.authorBekkouche, Nicolas
dc.contributor.authorChourrout, Daniel
dc.contributor.authorGómez-Skarmeta, José Luis
dc.contributor.authorIrimia, Manuel
dc.contributor.authorLenhard, Boris
dc.contributor.authorWorsaae, Katrine
dc.contributor.authorHejnol, Andreas
dc.description.abstractThe causes and consequences of genome reduction in animals are unclear because our understanding of this process mostly relies on lineages with often exceptionally high rates of evolution. Here, we decode the compact 73.8-megabase genome of Dimorphilus gyrociliatus, a meiobenthic segmented worm. The D. gyrociliatus genome retains traits classically associated with larger and slower-evolving genomes, such as an ordered, intact Hox cluster, a generally conserved developmental toolkit and traces of ancestral bilaterian linkage. Unlike some other animals with small genomes, the analysis of the D. gyrociliatus epigenome revealed canonical features of genome regulation, excluding the presence of operons and trans-splicing. Instead, the gene-dense D. gyrociliatus genome presents a divergent Myc pathway, a key physiological regulator of growth, proliferation and genome stability in animals. Altogether, our results uncover a conservative route to genome compaction in annelids, reminiscent of that observed in the vertebrate Takifugu rubripes.en_US
dc.publisherNature Researchen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleConservative route to genome compaction in a miniature anneliden_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright the authorsen_US
dc.source.journalNature Ecology and Evolutionen_US
dc.identifier.citationNature Ecology and Evolution. 2021, 5, 231–242.en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal