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dc.contributor.authorRiese, Peggy
dc.contributor.authorTrittel, Stephanie
dc.contributor.authorPathirana, Rishi
dc.contributor.authorKlawonn, Frank
dc.contributor.authorCox, Rebecca Jane
dc.contributor.authorGuzmán, Carlos A.
dc.date.accessioned2021-07-08T12:59:22Z
dc.date.available2021-07-08T12:59:22Z
dc.date.created2021-02-03T14:09:56Z
dc.date.issued2020-06-05
dc.identifier.issn2076-393X
dc.identifier.urihttps://hdl.handle.net/11250/2763947
dc.description.abstractInfluenza vaccination often results in a large percentage of low responders, especially in high-risk groups. As a first line of defense, natural killer (NK) cells play a crucial role in the fight against infections. However, their implication with regard to vaccine responsiveness is insufficiently assessed. Therefore, this study aimed at the validation of essential NK cell features potentially associated with differential vaccine responsiveness with a special focus on NKG2C- and/or CD57-expressing NK cells considered to harbor memory-like functions. To this end, 16 healthy volunteers were vaccinated with an adjuvanted pandemic influenza vaccine. Vaccine responders and low responders were classified according to their hemagglutination inhibition antibody titers. A majority of responders displayed enhanced frequencies of NKG2C-expressing NK cells 7- or 14-days post-vaccination as compared to low responders, whereas the expression of CD57 was not differentially modulated. The NK cell cytotoxic potential was found to be confined to CD56dimCD16+ NKG2C-expressing NK cells in the responders but not in the low responders, which was further confirmed by stochastic neighbor embedding analysis. The presented study is the first of its kind that ascribes CD56dimCD16+ NKG2C-expressing NK cells a crucial role in biasing adaptive immune responses upon influenza vaccination and suggests NKG2C as a potential biomarker in predicting pandemic influenza vaccine responsiveness.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleResponsiveness to influenza vaccination correlates with NKG2C-expression on NK cellsen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright the authorsen_US
dc.source.articlenumber281en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.3390/vaccines8020281
dc.identifier.cristin1886360
dc.source.journalVaccinesen_US
dc.relation.projectEU/Univax 601738en_US
dc.relation.projectNorges forskningsråd: 220670en_US
dc.relation.projectEU/IMI115672, FLUCOPen_US
dc.identifier.citationVaccines. 2020, 8, 281.en_US
dc.source.volume8en_US
dc.source.issue2en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal