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dc.contributor.authorJonker, Niels
dc.contributor.authorAslan, Berna
dc.contributor.authorBoned, Beatriz
dc.contributor.authorMarqués-García, Fernando
dc.contributor.authorRicos, Carmen
dc.contributor.authorAlvarez, Virtudes
dc.contributor.authorBartlett, William A.
dc.contributor.authorBraga, Federica
dc.contributor.authorCarobene, Anna
dc.contributor.authorCoşkun, Abdurrahman
dc.contributor.authorDíaz-Garzón, Jorge
dc.contributor.authorFernandez-Calle, Pilar
dc.contributor.authorGonzalez-Lao, Elisabet
dc.contributor.authorMinchinela, Joana
dc.contributor.authorPerich, Carmen
dc.contributor.authorSimón, Margarita
dc.contributor.authorSandberg, Sverre
dc.contributor.authorAarsand, Aasne Karine
dc.date.accessioned2021-07-12T11:27:19Z
dc.date.available2021-07-12T11:27:19Z
dc.date.created2020-11-11T12:48:40Z
dc.date.issued2020
dc.identifier.issn1434-6621
dc.identifier.urihttps://hdl.handle.net/11250/2764162
dc.descriptionPostponed access: the file will be available after 2021-10-03en_US
dc.description.abstractObjective: Kidney markers are some of the most frequently used laboratory tests in patient care, and correct clinical decision making depends upon knowledge and correct application of biological variation (BV) data. The aim of this study was to review available BV data and to provide updated BV estimates for the following kidney markers in serum and plasma; albumin, creatinine, cystatin C, chloride, potassium, sodium and urea. Content: Relevant studies were identified from a historical BV database as well as by systematic literature searches. Retrieved publications were appraised by the Biological Variation Data Critical Appraisal Checklist (BIVAC). Meta-analyses of BIVAC compliant studies with similar design were performed to deliver global estimates of within-subject (CVI) and between-subject (CVG) BV estimates. Out of the 61 identified papers, three received a BIVAC grade A, four grade B, 48 grade C, five grade D grade and one was not appraised as it did not report numerical BV estimates. Most studies were identified for creatinine (n=48). BV estimates derived from the meta-analysis were in general lower than previously reported estimates for all analytes except urea. For some measurands, BV estimates may be influenced by age or states of health, but further data are required. Summary: This review provides updated global BV estimates for kidney related measurands. For all measurands except for urea, these estimates were lower than previously reported. Outlook: For the measurands analyzed in this review, there are sufficient well-designed studies available to publish a trustworthy estimate of BV. However, for a number of newly appearing kidney markers no suitable data is available and additional studies are required.en_US
dc.language.isoengen_US
dc.publisherDe Gruyteren_US
dc.titleCritical appraisal and meta-analysis of biological variation estimates for kidney related analytesen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2020 Walter de Gruyter GmbHen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1515/cclm-2020-1168
dc.identifier.cristin1846929
dc.source.journalClinical Chemistry and Laboratory Medicineen_US
dc.identifier.citationClinical Chemistry and Laboratory Medicine. 2020.en_US


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