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dc.contributor.authorBorda, Miguel Germán
dc.contributor.authorJaramillo-Jiménez, Alberto
dc.contributor.authorOesterhus, Ragnhild
dc.contributor.authorSantacruz, José Manuel
dc.contributor.authorTovar-Rios, Diego Alejandro
dc.contributor.authorSønnesyn, Hogne
dc.contributor.authorCano-Gutierrez, Carlos Alberto
dc.contributor.authorVik‐Mo, Audun Osland
dc.contributor.authorAarsland, Dag
dc.description.abstractObjectives We aim to study the effects of the prescription of benzodiazepines and antidepressants on cognitive and functional decline in older adults living with Alzheimer's disease (AD) and Lewy body dementia (LBD) over a 5-year follow-up. Methods This is a longitudinal analysis of a Norwegian cohort study entitled “The Dementia Study of Western Norway” (DemVest). We included 196 patients newly diagnosed with AD (n = 111) and LBD (n = 85), followed annually for 5 years. Three prescription groups were defined: only benzodiazepines (BZD), only antidepressants (ADep), and the combination of benzodiazepines and antidepressants (BZD-ADep). Linear mixed-effects models were conducted to analyze the effect of the defined groups on the outcomes. The outcomes were functional decline, measured by the Rapid Disability Rating Scale—2, and cognition measured with the Mini-Mental State Examination. Results Prescription of the combination of benzodiazepines and antidepressants in LBD was associated with faster functional decline. In AD, the prescription of BZD and BZD-ADep was associated with greater functional deterioration. ADep alone did not show positive or negative significant associations with the studied outcomes. Conclusions BZD and especially the combination of BZD and ADep are associated with functional decline in AD and LBD and should be used cautiously.en_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.titleBenzodiazepines and antidepressants: Effects on cognitive and functional decline in Alzheimer's disease and Lewy body dementiaen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2021 The Authorsen_US
dc.source.journalInternational Journal of Geriatric Psychiatryen_US
dc.identifier.citationInternational Journal of Geriatric Psychiatry. 2021, 1-9.en_US

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Navngivelse-Ikkekommersiell 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse-Ikkekommersiell 4.0 Internasjonal