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dc.contributor.authorKlingen, Tor Audun
dc.contributor.authorChen, Ying
dc.contributor.authorAas, Hans
dc.contributor.authorWik, Elisabeth
dc.contributor.authorAkslen, Lars Andreas
dc.date.accessioned2021-08-10T07:47:22Z
dc.date.available2021-08-10T07:47:22Z
dc.date.created2021-04-13T13:54:45Z
dc.date.issued2021
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/11250/2767111
dc.description.abstractStromal elastosis is related to good prognosis in breast cancer and fibulin-2 helps to stabilize elastic fibers in basement membranes. Here, we examined the level of perivascular fibulin-2 expression in relation to elastosis content, vascular invasion, molecular subtypes, tumour detection mode, and patient prognosis in breast cancer. We performed a population based retrospective study of invasive breast cancers from the Norwegian Breast Screening Program (Vestfold County, 2004–2009) including 200 screen-detected and 82 interval cancers. Perivascular fibulin-2 staining was semi-quantitatively graded based on immunohistochemistry (1–3) and dichotomized as high expression (grade 2–3) and low expression (grade 1). Elastosis content was graded on a 4-tiered scale and dichotomized as high (score 3) and low (score 0–2) expression, whereas lymphatic (LVI) and blood vessel invasion (BVI) were recorded as absent or present by immunohistochemistry. High perivascular fibulin-2 expression was strongly related to stromal elastosis (p<0.001), and inversely associated with BVI and LVI (p<0.001 for both). High fibulin-2 was associated with luminal breast cancer subgroups (p<0.001) and inversely with interval cancers compared with screen-detected tumours (p<0.001). By univariate analysis, low perivascular fibulin-2 was associated with reduced recurrence-free survival (p = 0.002) and disease specific survival (p = 0.019). Low perivascular fibulin-2 expression was strongly related to vascular invasion, low stromal elastosis, non-luminal breast cancer subtypes, interval presentation, and adverse prognosis.en_US
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleFibulin-2 expression associates with vascular invasion and patient survival in breast canceren_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2021 Klingen et al.en_US
dc.source.articlenumbere0249767en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1371/journal.pone.0249767
dc.identifier.cristin1903812
dc.source.journalPLOS ONEen_US
dc.identifier.citationPLOS ONE. 2021, 16 (4), e0249767.en_US
dc.source.volume16en_US
dc.source.issue4en_US


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