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dc.contributor.authorBahadoer, Renu R.
dc.contributor.authorBastiaannet, Esther
dc.contributor.authorClaassen, Yvette H.M.
dc.contributor.authorvan der Mark, Marianne
dc.contributor.authorvan Eycken, Elizabeth
dc.contributor.authorVerbeeck, Julie
dc.contributor.authorGuren, Marianne
dc.contributor.authorKørner, Hartwig
dc.contributor.authorMartling, Anna
dc.contributor.authorJohansson, Robert
dc.contributor.authorvan de Velde, Cornelis J.H.
dc.contributor.authorDekker, Jan Willem T.
dc.date.accessioned2021-08-10T07:58:49Z
dc.date.available2021-08-10T07:58:49Z
dc.date.created2021-04-30T14:08:33Z
dc.date.issued2021
dc.identifier.issn0748-7983
dc.identifier.urihttps://hdl.handle.net/11250/2767118
dc.description.abstractBackground Mortality in the first postoperative year represents an accurate reflection of the perioperative risk after colorectal cancer surgery. This research compares one-year mortality after surgery divided into three age-categories (18-64, 65-74, ≥75 years), focusing on time trends and comparing treatment strategies. Material Population-based data of all patients diagnosed and treated surgically for stage I-III primary colorectal cancer from 2007 to 2016, were collected from Belgium, the Netherlands, Norway, and Sweden. Stratified for age-category and stage, treatment was evaluated, and 30-day, one-year and one-year excess mortality were calculated for colon and rectal cancer separately. Results were evaluated over two-year time periods. Results Data of 206,024 patients were analysed. Postoperative 30-day and one-year mortality reduced significantly over time in all countries and age-categories. Within the oldest age category, in 2015–2016, one-year excess mortality varied from 9% in Belgium to 4% in Sweden for colon cancer and, from 9% in Belgium to 3% in the other countries for rectal cancer. With increasing age, patients were less likely to receive additional therapy besides surgery. In Belgium, colon cancer patients were more often treated with adjuvant chemotherapy (p < 0.001). For neoadjuvant treatment of rectal cancer, patients in Belgium and Norway were mostly treated with chemoradiotherapy. In the Netherlands and Sweden, radiotherapy alone was preferred (p < 0.001). Conclusions Despite improvement over time in all countries and age-categories, substantial variation exists in one-year postoperative mortality. Differences in one-year excess postoperative mortality could be due to differences in treatment strategies, highlighting the consequences of under- and over-treatment on cancer survival.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleOne-year excess mortality and treatment in surgically treated patients with colorectal cancer: A EURECCA European comparisonen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2021 The Authorsen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1016/j.ejso.2021.01.011
dc.identifier.cristin1907478
dc.source.journalEuropean Journal of Surgical Oncologyen_US
dc.source.pagenumber1651-1660en_US
dc.identifier.citationEuropean Journal of Surgical Oncology. 2021, 47 (7), 1651-1660.en_US
dc.source.volume47en_US
dc.source.issue7en_US


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