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dc.contributor.authorNagel, Gabriele
dc.contributor.authorBjørge, Tone
dc.contributor.authorJaensch, Andrea
dc.contributor.authorPeter, Raphael Simon
dc.contributor.authorHäggström, Christel
dc.contributor.authorLang, Alois
dc.contributor.authorEngeland, Anders
dc.contributor.authorTeleka, Stanley
dc.contributor.authorJirström, Karin
dc.contributor.authorLindquist, David
dc.contributor.authorStattin, Pär
dc.contributor.authorUlmer, Hanno
dc.contributor.authorConcin, Hans
dc.contributor.authorStocks, Tanja
dc.date.accessioned2021-08-11T07:09:34Z
dc.date.available2021-08-11T07:09:34Z
dc.date.created2021-04-27T21:52:46Z
dc.date.issued2021
dc.identifier.issn0020-7136
dc.identifier.urihttps://hdl.handle.net/11250/2767270
dc.description.abstractTo explore the largely unknown etiology of small intestine cancer, we examinedmetabolic factors and risk of small intestine cancer overall and by subtypes. Among404 220 women and 403 265 men in six European cohorts, we applied Cox regressionwith adjustment for smoking and body mass index (BMI), to calculate sex-specific hazardratios (HRs) of small intestine cancer by levels of BMI, mean arterial pressure (MAP) andplasma total cholesterol, triglycerides and glucose. We also calculated HRs for these fac-tors combined (metabolic score; MetS) and used Wald test statistics to investigatepairwise interactions between metabolic factors on risk. We also performed analysesseparately per subtype (neuroendocrine tumors [NETs] and adenocarcinomas). During amedian follow-up of 16.9 years, 144 women and 195 men were diagnosed with smallintestine cancer, including 184 NETs and 99 adenocarcinomas. Among men, no mainassociations or interactions between metabolic factors were observed in relation to therisk of small intestine cancer. Among women,triglycerides were positively and linearlyassociated with risk (HR per standard deviation [SD]: 1.23, 95% confidence interval [CI]:1.04-1.46), and a positive association was also observed for the MetS (HR per SD: 1.25,95% CI: 1.02-1.52). Positive interactions were observed among women between triglyc-erides and cholesterol (P= .0005), and between MAP and glucose (P= .009), on risk. Glucose was positively associated with adenocarcinomas among women. This large, pro-spective study suggests that elevated triglycerides, and metabolic factors in interaction,confer an increased risk of small intestine cancer among women, but not among men.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titleMetabolic factors and the risk of small intestine cancers: Pooled study of 800 000 individuals in the metabolic syndrome and cancer projecten_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2021 The Authorsen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.doi10.1002/ijc.33530
dc.identifier.cristin1906814
dc.source.journalInternational Journal of Canceren_US
dc.source.pagenumber66-74en_US
dc.identifier.citationInternational Journal of Cancer. 2021, 149 (1), 66-74.en_US
dc.source.volume149en_US
dc.source.issue1en_US


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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