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dc.contributor.authorSinkeviciute, Igne
dc.contributor.authorHugdahl, Kenneth Jan
dc.contributor.authorBartz-Johannessen, Christoffer
dc.contributor.authorKroken, Rune Andreas
dc.contributor.authorLøberg, Else-Marie
dc.contributor.authorKjelby, Eirik
dc.contributor.authorRettenbacher, maria
dc.contributor.authorJoa, Inge
dc.contributor.authorReitan, Solveig Merete Klæbo
dc.contributor.authorAlisauskiene, Renata
dc.contributor.authorFathian, Farivar
dc.contributor.authorJohnsen, Erik
dc.description.abstractBackground Most studies investigating antipsychotic effectiveness report either total psychopathology or symptom cluster findings. Studies focusing on a separate symptom, such as hallucinations, a hallmark symptom in schizophrenia, are scarce. Therefore, the current study aims to compare the antihallucinatory effectiveness of 3 pharmacologically different antipsychotics: olanzapine, amisulpride, and aripiprazole. Methods The present study is part of the Bergen-Stavanger-Innsbruck-Trondheim study, a 12-month prospective, randomized, pragmatic antipsychotic drug trial in active-phase schizophrenia spectrum disorders. The primary outcome of the present study was change of hallucinations as measured by item P3 (hallucinatory behavior) from the Positive and Negative Syndrome Scale in the subgroup with hallucinations at baseline. Primary analyses were intention to treat. Results A total of 144 participants were included in the study, where 105 (72%) had a score of 3 or more on the Positive and Negative Syndrome Scale P3 item at baseline, indicating the presence of hallucinations (HALL subgroup). In the HALL subgroup, a significantly less reduction of hallucinations was revealed for participants using olanzapine in weeks 12, 26, 39, and 52 when compared with amisulpride and in weeks 26 and 52 when compared with aripiprazole. In subanalyses for participants never exposed to antipsychotic drugs (antipsychotic-naive) and those who had used antipsychotics before entering the study, antihallucinatory differences were revealed only in the latter group. Conclusions A differential antihallucinatory effect of the 3 study drugs was present. The inferior effect of olanzapine seems to be driven by the subgroup of participants exposed to antipsychotic treatment before entering the study.en_US
dc.publisherWolters Kluwer Healthen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleDifferential Effectiveness of Atypical Antipsychotics on Hallucinations: A Pragmatic Randomized Controlled Trialen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.source.journalJournal of Clinical Psychopharmacologyen_US
dc.identifier.citationJournal of Clinical Psychopharmacology. 2021, 41 (7/8), 389-396.en_US

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal