dc.contributor.author | Stoen, Maria J. | |
dc.contributor.author | Andersen, Sigve | |
dc.contributor.author | Rakaee, Mehrdad | |
dc.contributor.author | Pedersen, Mona I. | |
dc.contributor.author | Ingebriktsen, Lise M. | |
dc.contributor.author | Dønnem, Tom | |
dc.contributor.author | Lombardi, Ana P. G. | |
dc.contributor.author | Kilvaer, Thomas K. | |
dc.contributor.author | Rasmussen Busund, Lill-Tove | |
dc.contributor.author | Richardsen, Elin | |
dc.date.accessioned | 2021-09-10T13:14:38Z | |
dc.date.available | 2021-09-10T13:14:38Z | |
dc.date.created | 2021-08-30T17:38:16Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2072-6694 | |
dc.identifier.uri | https://hdl.handle.net/11250/2775250 | |
dc.description.abstract | Objective: assessing the prognostic role of miR-20a-5p, in terms of clinical outcome, in a large multi-institutional cohort study. Methods: Tissue microarrays from 535 patients’ prostatectomy specimens were constructed. In situ hybridization was performed to assess the expression level of miR-20a-5p in different tissue subregions: tumor stroma (TS) and tumor epithelium (TE). In vitro analysis was performed on prostate cancer cell lines. Results: A high miR-20a-5p expression was found negatively in association with biochemical failure in TE, TS and TE + TS (p = 0.001, p = 0.003 and p = 0.001, respectively). Multivariable analysis confirmed that high miR-20a-5p expression in TE independently predicts dismal prognosis for biochemical failure (HR = 1.56, 95% CI: 1.10–2.21, p = 0.014). Both DU145 and PC3 cells exhibited increased migration ability after transient overexpression of miR-20a-5p, as well as significant elevation of invasion in DU145 cells. Conclusion: A high miR-20a-5p expression in tumor epithelium is an independent negative predictor for biochemical prostate cancer recurrence. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Overexpression of mir-20a-5p in tumor epithelium is an independent negative prognostic indicator in prostate cancer—a multi-institutional study | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2021 the authors | en_US |
dc.source.articlenumber | 4096 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.3390/cancers13164096 | |
dc.identifier.cristin | 1929866 | |
dc.source.journal | Cancers | en_US |
dc.identifier.citation | Cancers. 2021, 13 (16), 4096. | en_US |
dc.source.volume | 13 | en_US |
dc.source.issue | 16 | en_US |