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dc.contributor.authorAndreou, Dimitrios
dc.contributor.authorSteen, Nils Eiel
dc.contributor.authorJørgensen, Kjetil Nordbø
dc.contributor.authorSmelror, Runar Elle
dc.contributor.authorWedervang-Resell, Kirsten
dc.contributor.authorNerland, Stener
dc.contributor.authorWestlye, Lars Tjelta
dc.contributor.authorNærland, Terje
dc.contributor.authorMyhre, Anne Margrethe
dc.contributor.authorJoa, Inge
dc.contributor.authorReitan, Solveig Merete Klæbo
dc.contributor.authorVaaler, Arne
dc.contributor.authorMorken, Gunnar
dc.contributor.authorBøen, Erlend
dc.contributor.authorElvsåshagen, Torbjørn
dc.contributor.authorBoye, Birgitte
dc.contributor.authorMalt, Ulrik Fredrik
dc.contributor.authorAukrust, Pål
dc.contributor.authorSkrede, Silje
dc.contributor.authorKroken, Rune Andreas
dc.contributor.authorJohnsen, Erik
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorAndreassen, Ole
dc.contributor.authorUeland, Thor
dc.contributor.authorAgartz, Ingrid
dc.description.abstractBackground: Both neurodegenerative and neurodevelopmental abnormalities have been suggested to be part of the etiopathology of severe mental illness (SMI). Neuron-specific enolase (NSE), mainly located in the neuronal cytoplasm, may indicate the process as it is upregulated after neuronal injury while a switch from non-neuronal enolase to NSE occurs during neuronal maturation. Methods: We included 1132 adult patients with SMI [schizophrenia (SZ) or bipolar spectrum disorders], 903 adult healthy controls (HC), 32 adolescent patients with SMI and 67 adolescent HC. Plasma NSE concentrations were measured by enzyme immunoassay. For 842 adults and 85 adolescents, we used total grey matter volume (TGMV) based on T1-weighted magnetic resonance images processed in FreeSurfer v6.0. We explored NSE case-control differences in adults and adolescents separately. To investigate whether putative case-control differences in NSE were TGMV-dependent we controlled for TGMV. Results: We found significantly lower NSE concentrations in both adult (p < 0.001) and adolescent patients with SMI (p = 0.007) compared to HC. The results remained significant after controlling for TGMV. Among adults, both patients with SZ spectrum (p < 0.001) and bipolar spectrum disorders (p = 0.005) had lower NSE than HC. In both patient subgroups, lower NSE levels were associated with increased symptom severity. Among adults (p < 0.001) and adolescents (p = 0.040), females had lower NSE concentrations than males. Conclusion: We found lower NSE concentrations in adult and adolescent patients with SMI compared to HC. The results suggest the lack of progressive neuronal injury, and may reflect abnormal neuronal maturation. This provides further support of a neurodevelopmental rather than a neurodegenerative mechanism in SMI.en_US
dc.publisherCambridge University Pressen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleLower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illnessen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2021 the authorsen_US
dc.source.journalPsychological Medicineen_US
dc.identifier.citationPsychological Medicine. 2021.en_US

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