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dc.contributor.authorIp, Hill F.
dc.contributor.authorvan der Laan, Camiel M.
dc.contributor.authorKrapohl, Eva M. L.
dc.contributor.authorBrikell, Isabell
dc.contributor.authorSánchez-Mora, Cristina
dc.contributor.authorNolte, Ilja M.
dc.contributor.authorPourcain, Beate St
dc.contributor.authorBolhuis, Koen
dc.contributor.authorPalviainen, Teemu
dc.contributor.authorZafarmand, Hadi
dc.contributor.authorColodro-Conde, Lucía
dc.contributor.authorGordon, Scott
dc.contributor.authorZayats, Tetyana
dc.contributor.authorAliev, Fazil
dc.contributor.authorJiang, Chang
dc.contributor.authorWang, Carol A.
dc.contributor.authorSaunders, Gretchen
dc.contributor.authorKarhunen, Ville
dc.contributor.authorHammerschlag, Anke R.
dc.contributor.authorAdkins, Daniel E.
dc.contributor.authorBorder, Richard
dc.contributor.authorPeterson, Roseann E.
dc.contributor.authorPrinz, Joseph A.
dc.contributor.authorThiering, Elisabeth
dc.contributor.authorSeppälä, Iikka
dc.contributor.authorVilor-Tejedor, Natàlia
dc.contributor.authorAhluwalia, Tarunveer S.
dc.contributor.authorDay, Felix R.
dc.contributor.authorHottenga, Jouke-Jan
dc.contributor.authorAllegrini, Andrea G.
dc.contributor.authorRimfeld, Kaili
dc.contributor.authorChen, Qi
dc.contributor.authorYi, Lu
dc.contributor.authorMartin, Joanna
dc.contributor.authorSoler Artigas, Marìa
dc.contributor.authorRovira, Paula
dc.contributor.authorBosch, Rosa
dc.contributor.authorEspañol, Gemma
dc.contributor.authorRamos-Quiroga, Josep Antonio
dc.contributor.authorNeumann, Alexander
dc.contributor.authorHaavik, Jan
dc.contributor.authorHarris, Jennifer Ruth
dc.contributor.authorHelgeland, Øyvind
dc.contributor.authorJohansson, Stefan
dc.contributor.authorKnudsen, Gun Peggy Strømstad
dc.contributor.authorNjølstad, Pål Rasmus
dc.contributor.authorHavdahl, Alexandra
dc.contributor.authorMagnus, Per Minor
dc.contributor.authorReichborn-Kjennerud, Ted
dc.contributor.authorBoomsma, Dorret I.
dc.date.accessioned2021-11-29T07:40:57Z
dc.date.available2021-11-29T07:40:57Z
dc.date.created2021-11-04T10:16:21Z
dc.date.issued2021
dc.identifier.issn2158-3188
dc.identifier.urihttps://hdl.handle.net/11250/2831787
dc.description.abstractChildhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors were included. We analyzed phenotype assessments for a total of 328 935 observations from 87 485 children aged between 1.5 and 18 years, while accounting for sample overlap. We also meta-analyzed within subsets of the data, i.e., within rater, instrument and age. SNP-heritability for the overall meta-analysis (AGGoverall) was 3.31% (SE = 0.0038). We found no genome-wide significant SNPs for AGGoverall. The gene-based analysis returned three significant genes: ST3GAL3 (P = 1.6E–06), PCDH7 (P = 2.0E–06), and IPO13 (P = 2.5E–06). All three genes have previously been associated with educational traits. Polygenic scores based on our GWAMA significantly predicted aggression in a holdout sample of children (variance explained = 0.44%) and in retrospectively assessed childhood aggression (variance explained = 0.20%). Genetic correlations (rg) among rater-specific assessment of AGG ranged from rg = 0.46 between self- and teacher-assessment to rg = 0.81 between mother- and teacher-assessment. We obtained moderate-to-strong rgs with selected phenotypes from multiple domains, but hardly with any of the classical biomarkers thought to be associated with AGG. Significant genetic correlations were observed with most psychiatric and psychological traits (range |rg|: 0.19–1.00), except for obsessive-compulsive disorder. Aggression had a negative genetic correlation (rg = ~−0.5) with cognitive traits and age at first birth. Aggression was strongly genetically correlated with smoking phenotypes (range |rg|: 0.46–0.60). The genetic correlations between aggression and psychiatric disorders were weaker for teacher-reported AGG than for mother- and self-reported AGG. The current GWAMA of childhood aggression provides a powerful tool to interrogate the rater-specific genetic etiology of AGG.en_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleGenetic association study of childhood aggression across raters, instruments, and ageen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright The Author(s) 2021en_US
dc.source.articlenumber413en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1038/s41398-021-01480-x
dc.identifier.cristin1951310
dc.source.journalTranslational Psychiatryen_US
dc.identifier.citationTranslational Psychiatry. 2021, 11, 413.en_US
dc.source.volume11en_US


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