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dc.contributor.authorFronczek, Jakub
dc.contributor.authorPolok, Kamil
dc.contributor.authorde Lange, Dylan W.
dc.contributor.authorJung, Christian
dc.contributor.authorBeil, Michael
dc.contributor.authorRhodes, Andrew
dc.contributor.authorFjølner, Jesper
dc.contributor.authorGórka, Jacek
dc.contributor.authorAndersen, Finn H.
dc.contributor.authorArtigas, Antonio
dc.contributor.authorCecconi, Maurizio
dc.contributor.authorChristensen, Steffen
dc.contributor.authorFlaatten, Hans
dc.contributor.authorSzczeklik, Wojciech
dc.date.accessioned2021-12-15T11:48:28Z
dc.date.available2021-12-15T11:48:28Z
dc.date.created2021-12-03T14:21:00Z
dc.date.issued2021
dc.identifier.issn1364-8535
dc.identifier.urihttps://hdl.handle.net/11250/2834412
dc.description.abstractBackground: The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after admission to the ICU. This study aimed to evaluate the influence of modelling approach on the association between the CFS score and short-term mortality and quantify the prognostic value of frailty in this context. Methods: We analysed data from two multicentre prospective cohort studies which enrolled intensive care unit patients ≥ 80 years old in 26 countries. The primary outcome was mortality within 30-days from admission to the ICU. Logistic regression models for both ICU and 30-day mortality included the CFS score as either a categorical, continuous or dichotomous variable and were adjusted for patient’s age, sex, reason for admission to the ICU, and admission Sequential Organ Failure Assessment score. Results: The median age in the sample of 7487 consecutive patients was 84 years (IQR 81–87). The highest fraction of new prognostic information from frailty in the context of 30-day mortality was observed when the CFS score was treated as either a categorical variable using all original levels of frailty or a nonlinear continuous variable and was equal to 9% using these modelling approaches (p < 0.001). The relationship between the CFS score and mortality was nonlinear (p < 0.01). Conclusion: Knowledge about a patient’s frailty status adds a substantial amount of new prognostic information at the moment of admission to the ICU. Arbitrary simplification of the CFS score into fewer groups than originally intended leads to a loss of information and should be avoided.en_US
dc.language.isoengen_US
dc.publisherBMCen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleRelationship between the Clinical Frailty Scale and short‑term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study.en_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2021 the authorsen_US
dc.source.articlenumber231en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.doi10.1186/s13054-021-03632-3
dc.identifier.cristin1964429
dc.source.journalCritical Careen_US
dc.identifier.citationCritical Care. 2021, 25, 231.en_US
dc.source.volume25en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal