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dc.contributor.authorBhan, Alok
dc.contributor.authorJacobsen, Cecilie
dc.contributor.authorDalen, Ingvild
dc.contributor.authorBergsland, Niels
dc.contributor.authorZivadinov, Robert
dc.contributor.authorAlves, Guido Werner
dc.contributor.authorMyhr, Kjell-Morten
dc.contributor.authorFarbu, Elisabeth
dc.description.abstractBackground Neurofilament light chain (NfL) is an attractive biomarker of disease activity and progression in MS, but there is a lack in long-term prognostic data. Objective To test the long-term clinical and radiological prognostic value of cerebrospinal fluid (CSF)-NfL among newly diagnosed patients with MS. Methods Newly diagnosed MS patients where followed prospectively with baseline CSF-NfL and repeated MRI and clinical assessments for up to 10 years. Associations between baseline CSF-NfL and longitudinal MRI and clinical assessments were found by Generalized Estimating Equations analysis. Results Forty-two participants were included. CSF-NfL at baseline was significantly associated with the rate of atrophy in globus pallidus (p = 0.009) and hippocampus (p = 0.001) as evaluated by MRI. Baseline volumes of thalamus (β −0.33; 95% CI −0.57 to −0.10, p = 0.006), T1 (β 0.28; 95% CI 0.11 to 0.44, p = 0.001) and T2 (β 0.16; 95% CI 0.04 to 0.27, p = 0.008) lesions and baseline levels of CSF-NfL (β 0.9; 95% CI 0.3 to 1.5, p = 0.002) significantly predicted EDSS worsening over 10 years. Baseline CSF-NfL gave a comparable prediction to the best MRI volumetric predictors. Conclusion CSF-NfL predicted the clinical and radiological course of newly diagnosed patients with MS over a 10-year period, underlining its prognostic role.en_US
dc.publisherSAGE Publicationsen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleCSF neurofilament light chain predicts 10-year clinical and radiologic worsening in multiple sclerosisen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright The Author(s) 2021en_US
dc.source.journalMultiple Sclerosis Journal, Experimental, Translational and Clinicalen_US
dc.identifier.citationMultiple Sclerosis Journal, Experimental, Translational and Clinical. 2021, 7 (4).en_US

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Navngivelse 4.0 Internasjonal
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