dc.contributor.author | Bhan, Alok | |
dc.contributor.author | Jacobsen, Cecilie | |
dc.contributor.author | Dalen, Ingvild | |
dc.contributor.author | Bergsland, Niels | |
dc.contributor.author | Zivadinov, Robert | |
dc.contributor.author | Alves, Guido Werner | |
dc.contributor.author | Myhr, Kjell-Morten | |
dc.contributor.author | Farbu, Elisabeth | |
dc.date.accessioned | 2022-01-20T10:23:26Z | |
dc.date.available | 2022-01-20T10:23:26Z | |
dc.date.created | 2021-12-16T12:03:52Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2055-2173 | |
dc.identifier.uri | https://hdl.handle.net/11250/2838440 | |
dc.description.abstract | Background
Neurofilament light chain (NfL) is an attractive biomarker of disease activity and progression in MS, but there is a lack in long-term prognostic data.
Objective
To test the long-term clinical and radiological prognostic value of cerebrospinal fluid (CSF)-NfL among newly diagnosed patients with MS.
Methods
Newly diagnosed MS patients where followed prospectively with baseline CSF-NfL and repeated MRI and clinical assessments for up to 10 years. Associations between baseline CSF-NfL and longitudinal MRI and clinical assessments were found by Generalized Estimating Equations analysis.
Results
Forty-two participants were included. CSF-NfL at baseline was significantly associated with the rate of atrophy in globus pallidus (p = 0.009) and hippocampus (p = 0.001) as evaluated by MRI. Baseline volumes of thalamus (β −0.33; 95% CI −0.57 to −0.10, p = 0.006), T1 (β 0.28; 95% CI 0.11 to 0.44, p = 0.001) and T2 (β 0.16; 95% CI 0.04 to 0.27, p = 0.008) lesions and baseline levels of CSF-NfL (β 0.9; 95% CI 0.3 to 1.5, p = 0.002) significantly predicted EDSS worsening over 10 years. Baseline CSF-NfL gave a comparable prediction to the best MRI volumetric predictors.
Conclusion
CSF-NfL predicted the clinical and radiological course of newly diagnosed patients with MS over a 10-year period, underlining its prognostic role. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SAGE Publications | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | CSF neurofilament light chain predicts 10-year clinical and radiologic worsening in multiple sclerosis | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright The Author(s) 2021 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1177/20552173211060337 | |
dc.identifier.cristin | 1969388 | |
dc.source.journal | Multiple Sclerosis Journal, Experimental, Translational and Clinical | en_US |
dc.identifier.citation | Multiple Sclerosis Journal, Experimental, Translational and Clinical. 2021, 7 (4). | en_US |
dc.source.volume | 7 | en_US |
dc.source.issue | 4 | en_US |