Prevalence of atherosclerosis and association with 5-year outcome: The Norwegian Stroke in the Young Study
dc.contributor.author | Nawaz, Beenish | |
dc.contributor.author | Fromm, Annette | |
dc.contributor.author | Øygarden, Halvor | |
dc.contributor.author | Eide, Geir E | |
dc.contributor.author | Saeed, Sahrai | |
dc.contributor.author | Meijer, Rudy | |
dc.contributor.author | Bots, Michiel L | |
dc.contributor.author | Sand, Kristin M | |
dc.contributor.author | Thomassen, Lars | |
dc.contributor.author | Næss, Halvor | |
dc.contributor.author | Waje-Andreassen, Ulrike | |
dc.date.accessioned | 2022-01-27T07:52:34Z | |
dc.date.available | 2022-01-27T07:52:34Z | |
dc.date.created | 2021-12-02T11:42:02Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2396-9873 | |
dc.identifier.uri | https://hdl.handle.net/11250/2876191 | |
dc.description.abstract | Objectives: We studied the prevalence of atherosclerosis among ischaemic stroke patients ≤60 years and controls at the time of the index stroke, and its association with occurrence of new cardiovascular events (CVEs) and mortality at a 5-year follow-up. Methods: Prevalent atherosclerosis was assessed for 385 patients and 260 controls in seven vascular areas by electrocardiogram (ECG), ankle–arm index (AAI) and measurement of right and left carotid and femoral intima-media thickness (cIMT and fIMT) and abdominal aorta plaques (AAP). Clinical end-points were any new CVE (stroke, angina, myocardial infarction or peripheral arterial disease) or death from any cause at 5-year follow-up. All results were sex- and age-adjusted; logistic regression and Cox proportional hazards models were applied. Results: Young patients ≤49 years had prevalent atherosclerosis in 1/2 of males and 1/3 of females. Compared with controls, young female patients showed significantly higher prevalent atherosclerosis, p = 0.024. Ischaemic ECG and mean cIMT were higher in young and middle-aged female patients (p = 0.044, p = 0.020, p = 0.023 and p <0.001, respectively). Mean fIMT was higher in middle-aged female patients (p <0.001). Cardiovascular events were associated with ischaemic ECG; AAI ≤0.9, fIMT ≥0.9 mm and increased number of areas with atherosclerosis (NAA) among patients, and with AAP, cIMT ≥0.9 mm, fIMT ≥0.9 mm and NAA among controls. Mortality was associated with higher age, ischaemic ECG and NAA among patients, and cIMT ≥0.9 mm among controls. Conclusion: Atherosclerosis is highly prevalent even in young stroke patients. Some areas and increasing NAA are associated with CVEs and death. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SAGE Publications | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Prevalence of atherosclerosis and association with 5-year outcome: The Norwegian Stroke in the Young Study | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright European Stroke Organisation 2021 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1177/23969873211059472 | |
dc.identifier.cristin | 1963318 | |
dc.source.journal | European Stroke Journal | en_US |
dc.source.pagenumber | 374-384 | en_US |
dc.identifier.citation | European Stroke Journal. 2021, 6 (4), 374-384. | en_US |
dc.source.volume | 6 | en_US |
dc.source.issue | 4 | en_US |
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