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dc.contributor.authorMunkvold, Bodil Karoline Ravn
dc.contributor.authorSolheim, Ole
dc.contributor.authorBartek, Jiri
dc.contributor.authorCorell, Alba
dc.contributor.authorDe Dios, Eddie
dc.contributor.authorGulati, Sasha
dc.contributor.authorHelseth, Eirik
dc.contributor.authorHolmgren, Klas
dc.contributor.authorJensdottir, Margret
dc.contributor.authorLundborg, Mina
dc.contributor.authorMireles, Eduardo Erasmo Mendoza
dc.contributor.authorMahesparan, Rupavathana
dc.contributor.authorTveiten, Øystein Vesterli
dc.contributor.authorMilos, Peter
dc.contributor.authorRedebrandt, Henrietta Nittby
dc.contributor.authorPedersen, Lars Kjelsberg
dc.contributor.authorRamm-Pettersen, Jon-Terje
dc.contributor.authorSjöberg, Rickard L
dc.contributor.authorSjögren, Björn
dc.contributor.authorSjåvik, Kristin
dc.contributor.authorSmits, Anja
dc.contributor.authorTomasevic, Gregor
dc.contributor.authorVecchio, Tomás Gómez
dc.contributor.authorVik-Mo, Einar O.
dc.contributor.authorZetterling, Maria
dc.contributor.authorSalvesen, Øyvind
dc.contributor.authorJakola, Asgeir Store
dc.description.abstractBackground Early extensive surgery is a cornerstone in treatment of diffuse low-grade gliomas (DLGGs), and an additional survival benefit has been demonstrated from early radiochemotherapy in selected “high-risk” patients. Still, there are a number of controversies related to DLGG management. The objective of this multicenter population-based cohort study was to explore potential variations in diagnostic work-up and treatment between treating centers in 2 Scandinavian countries with similar public health care systems. Methods Patients screened for inclusion underwent primary surgery of a histopathologically verified diffuse WHO grade II glioma in the time period 2012 through 2017. Clinical and radiological data were collected from medical records and locally conducted research projects, whereupon differences between countries and inter-hospital variations were explored. Results A total of 642 patients were included (male:female ratio 1:4), and annual age-standardized incidence rates were 0.9 and 0.8 per 100 000 in Norway and Sweden, respectively. Considerable inter-hospital variations were observed in preoperative work-up, tumor diagnostics, surgical strategies, techniques for intraoperative guidance, as well as choice and timing of adjuvant therapy. Conclusions Despite geographical population-based case selection, similar health care organizations, and existing guidelines, there were considerable variations in DLGG management. While some can be attributed to differences in clinical implementation of current scientific knowledge, some of the observed inter-hospital variations reflect controversies related to diagnostics and treatment. Quantification of these disparities renders possible identification of treatment patterns associated with better or worse outcomes and may thus represent a step toward more uniform evidence-based care.en_US
dc.publisherOxford University Pressen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleVariations in the management of diffuse low-grade gliomas - A Scandinavian multicenter studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.source.journalNeuro-Oncology Practiceen_US
dc.identifier.citationNeuro-Oncology Practice. 2021, 8 (6), 706-717.en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal