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dc.contributor.authorPape, Kathrine
dc.contributor.authorCowell, Whitney
dc.contributor.authorSejbaek, Camilla Sandal
dc.contributor.authorAndersson, Niklas Worm
dc.contributor.authorSvanes, Cecilie
dc.contributor.authorKolstad, Henrik A.
dc.contributor.authorLiu, Xiaoqin
dc.contributor.authorHougaard, Karin Sørig
dc.contributor.authorWright, Rosalind J.
dc.contributor.authorSchlünssen, Vivi
dc.date.accessioned2022-02-04T07:44:24Z
dc.date.available2022-02-04T07:44:24Z
dc.date.created2021-10-19T13:16:34Z
dc.date.issued2021
dc.identifier.issn0040-6376
dc.identifier.urihttps://hdl.handle.net/11250/2977024
dc.description.abstractObjective Research has linked early adverse childhood experiences (ACEs) with asthma development; however, existing studies have generally relied on parent report of exposure and outcome. We aimed to examine the association of early life ACEs with empirically determined trajectories of childhood asthma risk, using independent register information on both exposures and outcome. Methods Based on nationwide registries, we established a study cohort of 466 556 children born in Denmark (1997–2004). We obtained information on ACEs during the first 2 years of life (bereavement, parental chronic somatic and/or mental illness) and childhood asthma diagnosis or medication use from birth through age 10 years from the Danish National Patient and Prescription Registries, respectively. We identified asthma phenotypes using group-based trajectory modelling. We then used multinomial logistic regression to examine the association between early ACEs and asthma phenotypes. Results We identified four asthma phenotypes: non-asthmatic, early-onset transient, early-onset persistent and late-onset asthma. Girls with early-onset transient asthma (OR 1.13, 95% CI 1.04 to 1.24), early-onset persistent asthma (1.27, 95% CI 1.08 to 1.48) or late-onset asthma (OR 1.28, 95% CI 1.11 to 1.48) vs no asthma were more likely to have early life ACE exposure compared with girls without ACE exposure. Results were similar for boys who also had experienced early life ACEs with ORs of 1.16 (95% CI 1.08 to 1.25), 1.34 (95% CI 1.20 to 1.51) and 1.11 (95% CI 0.98 to 1.25), respectively. Conclusion In a nationwide-population study, we identified three childhood onset asthma phenotypes and found that ACEs early in life were associated with increased odds for each of these asthma phenotypes among both girls and boys.en_US
dc.language.isoengen_US
dc.publisherBMJ Publishing Groupen_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.no*
dc.titleAdverse childhood experiences and asthma: trajectories in a national cohorten_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright Author(s) (or their employer(s)) 2021.en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.doi10.1136/thoraxjnl-2020-214528
dc.identifier.cristin1947027
dc.source.journalThoraxen_US
dc.source.pagenumber547-553en_US
dc.identifier.citationThorax. 2021, 76 (6), 547-553.en_US
dc.source.volume76en_US
dc.source.issue6en_US


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Navngivelse-Ikkekommersiell 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse-Ikkekommersiell 4.0 Internasjonal