dc.contributor.author | Kringeland, Ester Anne | |
dc.contributor.author | Tell, Grethe S. | |
dc.contributor.author | Midtbø, Helga Bergljot | |
dc.contributor.author | Igland, Jannicke | |
dc.contributor.author | Haugsgjerd, Teresa Risan | |
dc.contributor.author | Gerdts, Eva | |
dc.date.accessioned | 2022-02-07T07:48:23Z | |
dc.date.available | 2022-02-07T07:48:23Z | |
dc.date.created | 2022-01-24T08:57:20Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 2047-4873 | |
dc.identifier.uri | https://hdl.handle.net/11250/2977356 | |
dc.description.abstract | Aims: Hypertension has been suggested as a stronger risk factor for acute coronary syndromes (ACS) in women than men. Whether this also applies to stage 1 hypertension [blood pressure (BP) 130–139/80–89 mmHg] is not known.
Methods and results: We tested associations of stage 1 hypertension with ACS in 12 329 participants in the Hordaland Health Study (mean baseline age 41 years, 52% women). Participants were grouped by baseline BP category: Normotension (BP < 130/80 mmHg), stage 1 and stage 2 hypertension (BP ≥140/90 mmHg). ACS was defined as hospitalization or death due to myocardial infarction or unstable angina pectoris during 16 years of follow-up. At baseline, a lower proportion of women than men had stage 1 and 2 hypertension, respectively (25 vs. 35% and 14 vs. 31%, P < 0.001). During follow-up, 1.4% of women and 5.7% of men experienced incident ACS (P < 0.001). Adjusted for diabetes, smoking, body mass index, cholesterol, and physical activity, stage 1 hypertension was associated with higher risk of ACS in women [hazard ratio (HR) 2.18, 95% confidence interval (CI) 1.32–3.60], while the association was non-significant in men (HR 1.30, 95% CI 0.98–1.71). After additional adjustment for systolic and diastolic BP, respectively, stage 1 diastolic hypertension was associated with ACS in women (HR 2.79 [95% CI 1.62-4.82]), but not in men (HR 1.24 [95% CI 0.95-1.62]), while stage 1 systolic hypertension was not associated with ACS in either sex.
Conclusion: Among subjects in their early 40s, stage 1 hypertension was a stronger risk factor for ACS during midlife in women than in men. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Oxford University Press | en_US |
dc.rights | Navngivelse-Ikkekommersiell 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/deed.no | * |
dc.title | Stage 1 hypertension, sex, and acute coronary syndromes during midlife: the Hordaland Health Study | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright The Author(s) 2021 | en_US |
dc.source.articlenumber | zwab068 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.doi | https://doi.org/10.1093/eurjpc/zwab068 | |
dc.identifier.cristin | 1988217 | |
dc.source.journal | European Journal of Preventive Cardiology (EJPC) | en_US |
dc.source.pagenumber | 147-154 | |
dc.identifier.citation | European Journal of Preventive Cardiology. 2022, 29 (1), 147-154. | en_US |
dc.source.volume | 29 | |
dc.source.issue | 1 | |