Show simple item record

dc.contributor.authorEkström, Magnus
dc.contributor.authorJohannessen, Ane
dc.contributor.authorAbramson, Michael J.
dc.contributor.authorBenediktsdóttir, Bryndís
dc.contributor.authorFranklin, Karl A.
dc.contributor.authorGislason, Thorarinn
dc.contributor.authorReal, Francisco Gomez
dc.contributor.authorHolm, Mathias
dc.contributor.authorJanson, Christer
dc.contributor.authorJogi, Rain
dc.contributor.authorLowe, Adrian J.
dc.contributor.authorMalinovschi, Andrei
dc.contributor.authorMartínez-Moratalla, Jesús
dc.contributor.authorOudin, Anna
dc.contributor.authorSánchez-Ramos, José Luis
dc.contributor.authorSchlünssen, Vivi
dc.contributor.authorSvanes, Cecilie
dc.description.abstractBackground Breathlessness is a major cause of suffering and disability globally. The symptom relates to multiple factors including asthma and lung function, which are influenced by hereditary factors. No study has evaluated potential inheritance of breathlessness itself across generations. Methods We analysed the association between breathlessness in parents and their offspring in the Respiratory Health in Northern Europe, Spain and Australia generation study. Data on parents and offspring aged ≥18 years across 10 study centres in seven countries included demographics, self-reported breathlessness, asthma, depression, smoking, physical activity level, measured Body Mass Index and spirometry. Data were analysed using multivariable logistic regression accounting for clustering within centres and between siblings. Results A total of 1720 parents (mean age at assessment 36 years, 55% mothers) and 2476 offspring (mean 30 years, 55% daughters) were included. Breathlessness was reported by 809 (32.7%) parents and 363 (14.7%) offspring. Factors independently associated with breathlessness in parents and offspring included obesity, current smoking, asthma, depression, lower lung function and female sex. After adjusting for potential confounders, parents with breathlessness were more likely to have offspring with breathlessness, adjusted OR 1.8 (95% CI 1.1 to 2.9). The association was not modified by sex of the parent or offspring. Conclusion Parents with breathlessness were more likely to have children who developed breathlessness, after adjusting for asthma, lung function, obesity, smoking, depression and female sex in both generations. The hereditary components of breathlessness need to be further explored.en_US
dc.publisherBMJ Publishing Groupen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleBreathlessness across generations: results from the RHINESSA generation studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright Author(s) (or their employer(s)) 2022.en_US
dc.identifier.citationThorax. 2022, 77 (2), 172-177.en_US

Files in this item


This item appears in the following Collection(s)

Show simple item record

Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal