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dc.contributor.authorKogelman, Lisette J.A.
dc.contributor.authorFalkenberg, Katrine
dc.contributor.authorBuil, Alfonso
dc.contributor.authorErola, Pau
dc.contributor.authorCourraud, Julie
dc.contributor.authorLaursen, Susan Svane
dc.contributor.authorMichoel, Tom Luk Robert
dc.contributor.authorOlesen, Jes
dc.contributor.authorHansen, Thomas F.
dc.description.abstractMigraine attacks are delimited, allowing investigation of changes during and outside attack. Gene expression fluctuates according to environmental and endogenous events and therefore, we hypothesized that changes in RNA expression during and outside a spontaneous migraine attack exist which are specific to migraine. Twenty-seven migraine patients were assessed during a spontaneous migraine attack, including headache characteristics and treatment effect. Blood samples were taken during attack, two hours after treatment, on a headache-free day and after a cold pressor test. RNA-Sequencing, genotyping, and steroid profiling were performed. RNA-Sequences were analyzed at gene level (differential expression analysis) and at network level, and genomic and transcriptomic data were integrated. We found 29 differentially expressed genes between ‘attack’ and ‘after treatment’, after subtracting non-migraine specific genes, that were functioning in fatty acid oxidation, signaling pathways and immune-related pathways. Network analysis revealed mechanisms affected by changes in gene interactions, e.g. ‘ion transmembrane transport’. Integration of genomic and transcriptomic data revealed pathways related to sumatriptan treatment, i.e. ‘5HT1 type receptor mediated signaling pathway’. In conclusion, we uniquely investigated intra-individual changes in gene expression during a migraine attack. We revealed both genes and pathways potentially involved in the pathophysiology of migraine and/or migraine treatment.en_US
dc.publisherNature Researchen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleChanges in the gene expression profile during spontaneous migraine attacksen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright The Author(s) 2021en_US
dc.source.journalScientific Reportsen_US
dc.identifier.citationScientific Reports. 2021, 11, 8294.en_US

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Navngivelse 4.0 Internasjonal
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