Short and Modular Synthesis of Substituted 2‑Aminopyrroles
Journal article, Peer reviewed
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OriginalversjonOrganic Letters. 2021, 23 (10), 4078-4082. 10.1021/acs.orglett.1c01345
We herein describe a simple and metal-free domino methodology to synthesize 2-aminopyrroles from alkynyl vinyl hydrazides. The domino reaction involves a novel propargylic 3,4-diaza-Cope rearrangement and a tandem isomerization/5-exo-dig N-cyclization reaction. By using this approach, a number of 2-aminopyrroles with diverse substituents have been prepared.