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dc.contributor.authorClasen, Joanna L
dc.contributor.authorHeath, Alicia K.
dc.contributor.authorVan Puyvelde, Heleen
dc.contributor.authorHuybrechts, Inge
dc.contributor.authorPark, Jin Young
dc.contributor.authorFerrari, Pietro
dc.contributor.authorJohansson, Mattias
dc.contributor.authorScelo, Ghislaine
dc.contributor.authorUlvik, Arve
dc.contributor.authorMidttun, Øivind
dc.contributor.authorUeland, Per Magne
dc.contributor.authorDahm, Christina C
dc.contributor.authorHalkjær, Jytte
dc.contributor.authorOlsen, Anja
dc.contributor.authorJohnson, Theron
dc.contributor.authorKatzke, Verena
dc.contributor.authorSchulze, Matthias B
dc.contributor.authorMasala, Giovanna
dc.contributor.authorSegrado, Francesco
dc.contributor.authorDe Magistris, Maria Santucci
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorOcké, Marga C
dc.contributor.authorLuján-Barroso, Leila
dc.contributor.authorChing-López, Ana
dc.contributor.authorHuerta, José María
dc.contributor.authorArdanaz, Eva
dc.contributor.authorAmiano, Pilar
dc.contributor.authorEricson, Ulrika
dc.contributor.authorManjer, Jonas
dc.contributor.authorGylling, Björn
dc.contributor.authorJohansson, Ingegerd
dc.contributor.authorSchmidt, Julie
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorRiboli, Elio
dc.contributor.authorCross, Amanda J
dc.contributor.authorMuller, David C
dc.description.abstractBackground Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5′-phosphate (PLP) is a commonly used measure of vitamin B6 status. Ratios of substrates indicating PLP coenzymatic function and metabolism may be useful complementary measures to further explore the role of vitamin B6 in health. Objectives We explored the sensitivity of 5 outcomes, namely PLP concentration, homocysteine:cysteine (Hcy:Cys), cystathionine:cysteine (Cysta:Cys), the 3´-hydroxykynurenine ratio (HKr), and the 4-pyridoxic acid ratio (PAr) to vitamin B6 intake as well as personal and lifestyle characteristics. Medthods Dietary intake and biomarker data were collected from participants from 3 nested case-control studies within the European Prospective Investigation into Cancer and Nutrition (EPIC). Bayesian regression models assessed the associations of the 5 biomarker outcomes with vitamin B6 intake and personal and lifestyle covariates. Analogous models examined the relations of Hcy:Cys, Cysta:Cys, and HKr with PLP. Results In total, 4608 participants were included in the analyses. Vitamin B6 intake was most strongly associated with PLP, moderately associated with Hcy:Cys, Cysta:Cys, and HKr, and not associated with PAr (fold change in marker given a doubling of vitamin B6 intake: PLP 1.60 [95% credible interval (CrI): 1.50, 1.71]; Hcy:Cys 0.87 [95% CrI: 0.84, 0.90]; Cysta:Cys 0.89 [95% CrI: 0.84, 0.94]; HKr 0.88 [95% CrI: 0.85, 0.91]; PAr 1.00 [95% CrI: 0.95, 1.05]). PAr was most sensitive to age, and HKr was least sensitive to BMI and alcohol intake. Sex and menopause status were strongly associated with all 5 markers. Conclusions We found that 5 different markers, capturing different aspects of vitamin B6–related biological processes, varied in their associations with vitamin B6 intake and personal and lifestyle predictors.en_US
dc.publisherOxford University Pressen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleA comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.source.journalAmerican Journal of Clinical Nutritionen_US
dc.identifier.citationAmerican Journal of Clinical Nutrition. 2021, 114 (1), 338-347.en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal