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dc.contributor.authorTriebner, Kai
dc.contributor.authorBifulco, Ersilia
dc.contributor.authorBarrera-Gómez, Jose
dc.contributor.authorBasagaña, Xavier
dc.contributor.authorBenediktsdóttir, Bryndís
dc.contributor.authorForsberg, Bertil
dc.contributor.authorFranklin, Karl A.
dc.contributor.authorGarcia-Larsen, Vanessa
dc.contributor.authorLeynaert, Bénédicte
dc.contributor.authorLindberg, Eva
dc.contributor.authorMartínez-Moratalla, Jesús
dc.contributor.authorMuniozguren-Agirre, Nerea
dc.contributor.authorPin, Isabelle
dc.contributor.authorRaherison, Chantal
dc.contributor.authorPereira-Vega, Antonio
dc.contributor.authorSchlünssen, Vivi
dc.contributor.authorValentin, Antonia
dc.contributor.authorHustad, Steinar
dc.contributor.authorReal, Francisco Gomez
dc.contributor.authorDadvand, Payam
dc.description.abstractBackground Solar ultraviolet radiation (UVR) affects the body through pathways that exhibit positive as well as negative health effects such as immunoregulation and vitamin D production. Different vitamin D metabolites are associated with higher or lower concentrations of estrogens and may thus alter the female sex hormone balance. Objective To study whether exposure to UVR, as a modifiable lifestyle factor, is associated with levels of sex hormones (17β-estradiol, estrone, estrone 3-sulfate, testosterone, dehydroepiandrosterone sulfate), gonadotropins (follicle stimulating hormone, luteinizing hormone) as well as sex hormone binding globulin in postmenopausal women, and thus investigate whether managing UVR exposure can influence the hormone balance, with potential benefits for the biological aging process. Methods The study included 580 postmenopausal women from six European countries, participating in the European Community Respiratory Health Survey (2010–2014). Average UVR exposure during the month before blood sampling was estimated based on personal sun behavior and ambient levels. Hormone concentrations were measured in serum using state-of-the-art methods. Subsequently we applied linear mixed-effects models, including center as random intercept, hormone concentrations (one at a time) as outcome and UVR, age, skin type, body mass index, vitamin D from dietary sources, smoking, age at completed full-time education and season of blood sampling as fixed-effect predictors. Results One interquartile range increase in UVR exposure was associated with decreased levels of 17β-estradiol (-15.6 pmol/L, 95 % Confidence Interval (CI): -27.69, -3.51) and estrone (-13.36 pmol/L, 95 % CI: -26.04, -0.68) and increased levels of follicle stimulating hormone (9.34IU/L, 95 % CI: 2.91, 15.77) and luteinizing hormone (13.86 IU/daL, 95 % CI: 2.48, 25.25). Conclusions Exposure to UVR is associated with decreased estrogens and increased gonadotropins in postmenopausal women, a status associated with osteoporosis, lung function decline and other adverse health effects. This study indicates that managing UVR exposure has potential to influence the hormone balance and counteract adverse health conditions after menopause.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleUltraviolet radiation as a predictor of sex hormone levels in postmenopausal women: A European multi-center study (ECRHS)en_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.identifier.citationMaturitas. 2021, 145, 49-55.en_US

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