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dc.contributor.authorPavlovic, Nikola
dc.contributor.authorChierchia, Gian-Battista
dc.contributor.authorVelagic, Vedran
dc.contributor.authorHermida, Jean Sylvain
dc.contributor.authorHealey, Stewart
dc.contributor.authorArena, Giuseppe
dc.contributor.authorBadenco, Nicolas
dc.contributor.authorMeyer, Christian
dc.contributor.authorChen, Jian
dc.contributor.authorIacopino, Saverio
dc.contributor.authorAnselme, Frédéric
dc.contributor.authorDekker, Lukas
dc.contributor.authorScazzuso, Fernando
dc.contributor.authorPacker, Douglas L.
dc.contributor.authorde Asmundis, Carlo
dc.contributor.authorPitschner, Heinz-Friedrich
dc.contributor.authorPiazza, Fabio Di
dc.contributor.authorKaplon, Rachelle E.
dc.contributor.authorKuniss, Malte
dc.description.abstractBackground Cryoballoon ablation (CBA) as a first-line rhythm control strategy is superior to antiarrhythmic drugs (AADs) for preventing atrial fibrillation (AF) recurrence; the impact of first-line CBA on quality of life (QoL) and symptoms has not been well characterized. Methods Patients aged 18 to 75 with symptomatic paroxysmal AF naïve to rhythm control therapy were randomized (1:1) to CBA (Arctic Front Advance, Medtronic) or AAD (Class I or III). Symptoms and QoL were assessed at baseline, 1, 3, 6, 9, and 12 months using the EHRA classification and Atrial Fibrillation Effect on QualiTy-of-Life (AFEQT) and SF-36v2 questionnaires. Symptomatic palpitations were evaluated via patient diary. Results Overall, 107 patients were randomized to CBA and 111 to AAD; crossovers occurred in 9%. Larger improvements in the AFEQT summary, subscale and treatment satisfaction scores were observed at 12 months with CBA vs AAD (all P <0.05). At 12 months, the mean adjusted difference in the AFEQT summary score was 9.9 points higher in the CBA group (95% CI: 5.5 –14.2, P <0.001). Clinically important improvements in the SF-36 physical and mental component scores were observed at 12 months in both groups, with no significant between group differences at this timepoint. In the CBA vs AAD group, larger improvements in EHRA class were observed at 6, 9 and 12 months (P <0.05) and the incidence rate of symptomatic palpitations was lower (4.6 vs 15.2 days/year post-blanking; IRR: 0.30, P <0.001). Conclusions In patients with symptomatic AF, first-line CBA was superior to AAD for improving AF-specific QoL and symptoms.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleInitial rhythm control with cryoballoon ablation vs drug therapy: Impact on quality of life and symptomsen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.source.journalAmerican Heart Journalen_US
dc.identifier.citationAmerican Heart Journal. 2021, 242, 103-114.en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal