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dc.contributor.authorSöderström, Elisabet
dc.contributor.authorNilsson, Torbjörn K.
dc.contributor.authorSchneede, Jörn
dc.contributor.authorUeland, Per-Magne
dc.contributor.authorMidttun, Øivind
dc.contributor.authorGylling, Björn
dc.contributor.authorJohansson, Ingegerd
dc.contributor.authorHultdin, Johan
dc.description.abstractPlasma total homocysteine (tHcy) is a risk marker, and smoking is an established risk factor for cardiovascular disease. It is unclear if the effect of smoked tobacco on homocysteine is mediated by nicotine or other combustion products in smoked tobacco. Snus (moist smokeless tobacco) is high nicotine-containing tobacco, and little is known about the effect of snus on plasma homocysteine. Therefore, we studied, in a cross-section of subjects (n = 1375) from the Northern Sweden Health and Disease Study, with strictly defined current smokers (n = 194) and snus users (n = 47), the impact of tobacco exposure on tHcy, assessed by self-reported tobacco habits and plasma cotinine concentrations. The snus users had higher cotinine concentrations than the smokers. Cotinine, creatinine, methylmalonic acid, and the methylenetetrahydrofolate reductase genotype (MTHFR) T allele were positively associated with tHcy among the smokers, but not among the snus users. No association was observed between tHcy and the number of cigarettes/day. There was a positive association between cotinine and tHcy in the smokers, but not among the snus users. This indicates that substances other than nicotine in tobacco smoke could be responsible for the differential effects on homocysteine status. Self-reported smoking should be complemented by a cotinine assay whenever possible.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titlePlasma cotinine is positively associated with homocysteine in smokers but not in users of smokeless tobaccoen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.source.journalInternational Journal of Environmental Research and Public Health (IJERPH)en_US
dc.identifier.citationInternational Journal of Environmental Research and Public Health (IJERPH). 2021, 18 (21), 11365.en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal