Heat shock factor 1 (Hsf1) cooperates with estrogen receptor α (erα) in the regulation of estrogen action in breast cancer cells
dc.contributor.author | Vydra, Natalia | |
dc.contributor.author | Janus, Patryk | |
dc.contributor.author | Kuś, Paweł | |
dc.contributor.author | Stokowy, Tomasz | |
dc.contributor.author | Mrowiec, Katarzyna | |
dc.contributor.author | Toma-Jonik, Agnieszka | |
dc.contributor.author | Krzywon, Aleksandra | |
dc.contributor.author | Cortez, Alexander Jorge | |
dc.contributor.author | Wojtaś, Bartosz | |
dc.contributor.author | Gielniewski, Bartłomiej | |
dc.contributor.author | Jaksik, Roman | |
dc.contributor.author | Kimmel, Marek | |
dc.contributor.author | Widłak, Wiesława | |
dc.date.accessioned | 2022-04-20T13:05:51Z | |
dc.date.available | 2022-04-20T13:05:51Z | |
dc.date.created | 2021-12-13T21:58:40Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2050-084X | |
dc.identifier.uri | https://hdl.handle.net/11250/2991672 | |
dc.description.abstract | Heat shock factor 1 (HSF1), a key regulator of transcriptional responses to proteotoxic stress, was linked to estrogen (E2) signaling through estrogen receptor α (ERα). We found that an HSF1 deficiency may decrease ERα level, attenuate the mitogenic action of E2, counteract E2-stimulated cell scattering, and reduce adhesion to collagens and cell motility in ER-positive breast cancer cells. The stimulatory effect of E2 on the transcriptome is largely weaker in HSF1-deficient cells, in part due to the higher basal expression of E2-dependent genes, which correlates with the enhanced binding of unliganded ERα to chromatin in such cells. HSF1 and ERα can cooperate directly in E2-stimulated regulation of transcription, and HSF1 potentiates the action of ERα through a mechanism involving chromatin reorganization. Furthermore, HSF1 deficiency may increase the sensitivity to hormonal therapy (4-hydroxytamoxifen) or CDK4/6 inhibitors (palbociclib). Analyses of data from The Cancer Genome Atlas database indicate that HSF1 increases the transcriptome disparity in ER-positive breast cancer and can enhance the genomic action of ERα. Moreover, only in ER-positive cancers an elevated HSF1 level is associated with metastatic disease. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | eLife | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Heat shock factor 1 (Hsf1) cooperates with estrogen receptor α (erα) in the regulation of estrogen action in breast cancer cells | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2021 The Author(s) | en_US |
dc.source.articlenumber | e69843 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.doi | 10.7554/eLife.69843 | |
dc.identifier.cristin | 1967985 | |
dc.source.journal | eLIFE | en_US |
dc.identifier.citation | eLIFE. 2021, 10, e69843. | en_US |
dc.source.volume | 10 | en_US |
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