• norsk
    • English
  • English 
    • norsk
    • English
  • Login
View Item 
  •   Home
  • University of Bergen Library
  • Registrations from Cristin
  • View Item
  •   Home
  • University of Bergen Library
  • Registrations from Cristin
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

European Biological Variation Study (EuBIVAS): Within- and between-subject biological variation estimates for serum thyroid biomarkers based on weekly samplings from 91 healthy participants

Bottani, Michela; Aarsand, Aasne Karine; Banfi, Giuseppe; Locatelli, Massimo; Coşkun, Abdurrahman; Díaz-Garzón, Jorge; Fernandez-Calle, Pilar; Sandberg, Sverre; Ceriotti, Ferruccio; Carobene, Anna
Journal article, Peer reviewed
Published version
Thumbnail
View/Open
PDF (413.3Kb)
URI
https://hdl.handle.net/11250/2991675
Date
2022
Metadata
Show full item record
Collections
  • Department of Global Public Health and Primary Care [3511]
  • Registrations from Cristin [12990]
Original version
Clinical Chemistry and Laboratory Medicine. 2022, 60 (4), 523-532.   10.1515/cclm-2020-1885
Abstract
Objectives: Thyroid biomarkers are fundamental for the diagnosis of thyroid disorders and for the monitoring and treatment of patients with these diseases. The knowledge of biological variation (BV) is important to define analytical performance specifications (APS) and reference change values (RCV). The aim of this study was to deliver BV estimates for thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), thyroglobulin (TG), and calcitonin (CT).

Methods: Analyses were performed on serum samples obtained from the European Biological Variation Study population (91 healthy individuals from six European laboratories; 21–69 years) on the Roche Cobas e801 at the San Raffaele Hospital (Milan, Italy). All samples from each individual were evaluated in duplicate within a single run. The BV estimates with 95% CIs were obtained by CV-ANOVA, after analysis of variance homogeneity and outliers.

Results: The within-subject (CV I ) BV estimates were for TSH 17.7%, FT3 5.0%, FT4 4.8%, TG 10.3, and CT 13.0%, all significantly lower than those reported in the literature. No significant differences were observed for BV estimates between men and women.

Conclusions: The availability of updated, in the case of CT not previously published, BV estimates for thyroid markers based on the large scale EuBIVAS study allows for refined APS and associated RCV applicable in the diagnosis and management of thyroid and related diseases.
Publisher
De Gruyter
Journal
Clinical Chemistry and Laboratory Medicine
Copyright
Copyright 2021 Walter de Gruyter

Contact Us | Send Feedback

Privacy policy
DSpace software copyright © 2002-2019  DuraSpace

Service from  Unit
 

 

Browse

ArchiveCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsDocument TypesJournalsThis CollectionBy Issue DateAuthorsTitlesSubjectsDocument TypesJournals

My Account

Login

Statistics

View Usage Statistics

Contact Us | Send Feedback

Privacy policy
DSpace software copyright © 2002-2019  DuraSpace

Service from  Unit