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dc.contributor.authorTesli, Martin Steen
dc.contributor.authorDegerud, Eirik Magnus Meek
dc.contributor.authorPlana-Ripoll, Oleguer
dc.contributor.authorGustavson, Kristin
dc.contributor.authorTorvik, Fartein Ask
dc.contributor.authorYstrøm, Eivind
dc.contributor.authorAsk, Helga
dc.contributor.authorTesli, Natalia
dc.contributor.authorHøye, Anne
dc.contributor.authorStoltenberg, Camilla
dc.contributor.authorReichborn-Kjennerud, Ted
dc.contributor.authorNæss, Øyvind Erik
dc.contributor.authorNesvåg, Ragnar
dc.description.abstractBackground Individuals suffering from schizophrenia have a reduced life expectancy with cardiovascular disease (CVD) as a major contributor. Low educational attainment is associated with schizophrenia, as well as with all-cause and CVD mortality. However, it is unknown to what extent low educational attainment can explain the increased mortality in individuals with schizophrenia. Aim Here, we quantify associations between educational attainment and all-cause and CVD mortality in individuals with schizophrenia, and compare them with the corresponding associations in the general population. Method All Norwegian citizens born between January 1, 1925, and December 31, 1959, were followed up from January 1, 1990, to December 31, 2014. The total sample included 1,852,113 individuals, of which 6548 were registered with schizophrenia. We estimated hazard ratios (HR) for all-cause and CVD mortality with Cox models, in addition to life years lost. Educational attainment for index persons and their parents were included in the models. Results In the general population individuals with low educational attainment had higher risk of all-cause (HR: 1.48 [95% CI: 1.47–1.49]) and CVD (HR: 1.59 [95% CI: 1.57–1.61]) mortality. In individuals with schizophrenia these estimates were substantially lower (all-cause: HR: 1.13 [95% CI: 1.05–1.21] and CVD: HR: 1.12 [95% CI: 0.98–1.27]). Low educational attainment accounted for 3.28 (3.21–3.35) life years lost in males and 2.48 (2.42–2.55) years in females in the general population, but was not significantly associated with life years lost in individuals with schizophrenia. Results were similar for parental educational attainment. Conclusions Our results indicate that while individuals with schizophrenia in general have lower educational attainment and higher mortality rates compared with the general population, the association between educational attainment and mortality is smaller in schizophrenia subjects than in the general population.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleEducational attainment and mortality in schizophreniaen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.source.journalActa Psychiatrica Scandinavicaen_US
dc.relation.projectNorges forskningsråd: 240220en_US
dc.identifier.citationActa Psychiatrica Scandinavica. 2022, 145 (5), 481-493.en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal