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dc.contributor.authorAlhourani, Abdelnour
dc.contributor.authorFørde, Jan-Lukas
dc.contributor.authorNasrollahzadeh, Mojdeh
dc.contributor.authorEichacker, Lutz Andreas
dc.contributor.authorHerfindal, Lars
dc.contributor.authorHagland, Hanne Røland
dc.date.accessioned2022-05-27T12:23:46Z
dc.date.available2022-05-27T12:23:46Z
dc.date.created2022-03-29T00:02:56Z
dc.date.issued2022
dc.identifier.issn2516-0230
dc.identifier.urihttps://hdl.handle.net/11250/2996480
dc.description.abstractGraphene is an attractive choice for the development of an effective drug carrier in cancer treatment due to its high adsorption area and pH-responsive drug affinity. In combination with the highly potent metabolic drug phenformin, increased doses could be efficiently delivered to cancer cells. This study compares the use of graphene oxide (GO) and polyethylene glycol stabilized (PEGylated) pristine graphene nanosheets (PGNSs) for drug delivery applications with phenformin. The cytotoxicity and mitotoxicity of the graphene-based systems were assessed in human cells and zebrafish larvae. Targeted drug release from GO and PGNSs was evaluated at different pH levels known to arise in proliferating tumor microenvironments. PGNSs were less cytotoxic and mitotoxic than GO, and showed an increased release of phenformin at lower pH in cells, compared to GO. In addition, the systemic phenformin effect was mitigated in zebrafish larvae when bound to GO and PGNSs compared to free phenformin, as measured by flavin metabolic lifetime imaging. These results pave the way for improved phenformin-based cancer therapy using graphene nano-sheets, where PGNSs were superior to GO.en_US
dc.language.isoengen_US
dc.publisherRoyal Society of Chemistryen_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.no*
dc.titleGraphene-based phenformin carriers for cancer cell treatment: a comparative study between oxidized and pegylated pristine graphene in human cells and zebrafishen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2022 the authorsen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1039/d1na00778e
dc.identifier.cristin2013180
dc.source.journalNanoscale Advancesen_US
dc.source.pagenumber1668-1680en_US
dc.identifier.citationNanoscale Advances. 2022, 4 (6), 1668-1680.en_US
dc.source.volume4en_US
dc.source.issue6en_US


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Navngivelse-Ikkekommersiell 4.0 Internasjonal
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