dc.contributor.author | Streng, Koen W. | |
dc.contributor.author | Hillege, Hans L. | |
dc.contributor.author | ter Maaten, Jozine M. | |
dc.contributor.author | van Veldhuisen, Dirk J. | |
dc.contributor.author | Dickstein, Kenneth | |
dc.contributor.author | Ng, Leong L. | |
dc.contributor.author | Samani, Nilesh J. | |
dc.contributor.author | Metra, Marco | |
dc.contributor.author | Ponikowski, Piotr | |
dc.contributor.author | Cleland, John G. | |
dc.contributor.author | Anker, Stefan D. | |
dc.contributor.author | Romaine, Simon P.R. | |
dc.contributor.author | Damman, Kevin | |
dc.contributor.author | van der Meer, Peter | |
dc.contributor.author | Lang, Chim C. | |
dc.contributor.author | Voors, Adriaan A. | |
dc.date.accessioned | 2022-05-27T13:16:25Z | |
dc.date.available | 2022-05-27T13:16:25Z | |
dc.date.created | 2022-04-23T12:23:04Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 2190-5991 | |
dc.identifier.uri | https://hdl.handle.net/11250/2996514 | |
dc.description.abstract | Background: A higher protein intake has been associated with a higher muscle mass and lower mortality rates in the general population, but data about protein intake and survival in patients with heart failure (HF) are lacking.
Methods: We studied the prevalence, predictors, and clinical outcome of estimated protein intake in 2516 patients from the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT-CHF) index cohort. Protein intake was calculated in spot urine samples using a validated formula [13.9 + 0.907 * body mass index (BMI) (kg/m2) + 0.0305 * urinary urea nitrogen level (mg/dL)]. Association with mortality was assessed using multivariable Cox regression models. All findings were validated in an independent cohort.
Results: We included 2282 HF patients (mean age 68 ± 12 years and 27% female). Lower estimated protein intake in HF patients was associated with a lower BMI, but with more signs of congestion. Mortality rate in the lowest quartile was 32%, compared with 18% in the highest quartile (P < 0.001). In a multivariable model, lower estimated protein intake was associated with a higher risk of death compared with the highest quartile [hazard ratio (HR) 1.50; 95% confidence interval (CI) 1.03–2.18, P = 0.036 for the lowest quartile and HR 1.46; 95% CI 1.00–2.18, P = 0.049 for the second quartile].
Conclusions: An estimated lower protein intake was associated with a lower BMI, but signs of congestion were more prevalent. A lower estimated protein intake was independently associated with a higher mortality risk. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Clinical implications of low estimated protein intake in patients with heart failure | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2022 the authors | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1002/jcsm.12973 | |
dc.identifier.cristin | 2018580 | |
dc.source.journal | Journal of Cachexia, Sarcopenia and Muscle | en_US |
dc.identifier.citation | Journal of Cachexia, Sarcopenia and Muscle. 2022. | en_US |