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dc.contributor.authorLiu, Jian Hao
dc.contributor.authorPeter, David Olukoya
dc.contributor.authorGuttormsen, Maren Sofie Faldalen
dc.contributor.authorHossain, Md Kaykobad
dc.contributor.authorGerking, Yola
dc.contributor.authorVeruki, Margaret Lin
dc.contributor.authorHartveit, Espen
dc.description.abstractThe vertebrate retina contains a large number of different types of neurons that can be distinguished by their morphological properties. Assuming that no location should be without a contribution from the circuitry and function linked to a specific type of neuron, it is expected that the dendritic trees of neurons belonging to a type will cover the retina in a regular manner. Thus, for most types of neurons, the contribution to visual processing is thought to be independent of the exact location of individual neurons across the retina. Here, we have investigated the distribution of AII amacrine cells in rat retina. The AII is a multifunctional amacrine cell found in mammals and involved in synaptic microcircuits that contribute to visual processing under both scotopic and photopic conditions. Previous investigations have suggested that AIIs are regularly distributed, with a nearest-neighbor distance regularity index of ~4. It has been argued, however, that this presumed regularity results from treating somas as points, without taking into account their actual spatial extent which constrains the location of other cells of the same type. When we simulated random distributions of cell bodies with size and density similar to real AIIs, we confirmed that the simulated distributions could not be distinguished from the distributions observed experimentally for AIIs in different regions and eccentricities of the retina. The developmental mechanisms that generate the observed distributions of AIIs remain to be investigated.en_US
dc.publisherCambridge University Pressen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.subjectNeurovitenskap / nevrovitenskapen_US
dc.subjectVisual neuroscienceen_US
dc.subjectVisual neuroscienceen_US
dc.titleThe mosaic of AII amacrine cell bodies in rat retina is indistinguishable from a random distributionen_US
dc.title.alternativeThe mosaic of AII amacrine cell bodies in rat retina is indistinguishable from a random distributionen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright The Author(s), 2022en_US
dc.source.journalVisual Neuroscienceen_US
dc.relation.projectNorges forskningsråd: 261914en_US
dc.subject.nsiVDP::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.subject.nsiVDP::Basic medical, dental and veterinary sciences: 710en_US
dc.identifier.citationVisual Neuroscience. 2022, 39, E004.en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal