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dc.contributor.authorKovac, Nina
dc.contributor.authorGrymyr, Lisa Marie Dale
dc.contributor.authorGerdts, Eva
dc.contributor.authorNadirpour, Saied
dc.contributor.authorNedrebø, Bjørn Gunnar
dc.contributor.authorHjertaas, Johannes Just
dc.contributor.authorMatre, Knut
dc.contributor.authorCramariuc, Dana
dc.date.accessioned2022-06-07T12:20:45Z
dc.date.available2022-06-07T12:20:45Z
dc.date.created2022-04-30T14:33:25Z
dc.date.issued2022
dc.identifier.issn2077-0383
dc.identifier.urihttps://hdl.handle.net/11250/2997718
dc.description.abstractBackground: Aortic valve sclerosis (AVS), mitral valve sclerosis (MVS), remodeling of major arteries, and increased pericardial fat are associated with subclinical atherosclerosis. We assessed these markers of atherosclerosis in severely obese patients before and 1 year after bariatric surgery. Methods: Eighty-seven severely obese patients (43 ± 10 years, preoperative body mass index [BMI] 41.8 ± 5 kg/m2) underwent echocardiography before and 1 year after Roux-en-Y bypass surgery in the FatWest (Bariatric Surgery on the West Coast of Norway) study. We measured the end-diastolic aortic wall thickness (AWT), pericardial fat thickness at the right ventricular free wall, and AVS/MVS based on combined aortic leaflet thickness and hyperechoic valve lesions. Results: Postoperatively, patients experienced a reduction of 12.9 ± 3.9 kg/m2 in BMI, 0.5 ± 1.9 mm in AWT, 2.6 ± 2.3 mm in pericardial fat, and 45%/53% in AVS/MVS (p < 0.05). In multivariate regression analyses with adjustment for clinical and hemodynamic variables, less pericardial fat reduction was associated with male sex and higher 1-year blood pressure and BMI, and less AWT-reduction with higher age and 1-year BMI (p < 0.05). Persistent AVS and MVS were related to higher 1-year BMI and more advanced valve sclerosis preoperatively (p < 0.05). Conclusions: Markers of subclinical atherosclerosis decreases significantly 1 year after bariatric surgery, particularly in younger patients that achieve a BMI < 28 kg/m2.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleMarkers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgeryen_US
dc.title.alternativeMarkers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgeryen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2022 by the authorsen_US
dc.source.articlenumber2237en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.3390/jcm11082237
dc.identifier.cristin2020337
dc.source.journalJournal of Clinical Medicineen_US
dc.identifier.citationJournal of Clinical Medicine. 2022, 11 (8), 2237.en_US
dc.source.volume11en_US
dc.source.issue8en_US


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